Alert! Anti-inflammatory bowel disease drugs cause these diseases!

!---- inflammatory bowel disease (IBD) is a chronic recurrent inflammatory inflammatory disease of an abnormally immune-mediated nonspecific intestinal chronic inflammatory disease caused by a variety of etiology, characterized by inflammation of the digestive tract and mucosa damage, including ulcerative colitis (UC), Crohn's disease (CD) and unstereotyped colitis (IC), whose clinical manifestations are diverse and can also be associated with almost all organs and systems, such as immune systemsIBD treatment drugs are mainly amino salicylic acid preparations, glucocorticoids, immunosuppressants, biologics and so onMost drugsIBD drug-related pancreatitis for ibD treatment, such as thionine, 5-aminosic salicylic acid, lyunine sulfonate, biologics, glucocorticoids, etc., may be associated with an increased risk of pancreatitis, and may be related to direct toxicity, high sensitivity, secondary hyperlipidemia or hypercalcemiaIBD drug-associated pancreatitis usually appears in the first few weeks, manifested as a mild clinical course, will soon heal once discontinued, there are also 4 to 6 months after the use of the drug, very few after long-term drug use induced acute pancreatitis (AP)the clinical characteristics of the drug thionine thiopental is the most common drug to induce AP in IBD treatmentusually occurs in the first month, and women are at higher risk of having AP, smoking is the most important risk factor for drug-induced APMesala Qin MeisalaQin (5-aminosic salicylic acid) can induce pancreatitis, which induces AP at 7 times the risk of ljuxalamineMaysalaqin may induce AP 2d to 2 years after the start of the drug, most of which occur within 6 weeks of taking the drug, and clinical improvement usually occurs within 4d after discontinuationis rare for phytozoa to induce pancreatitis, and its induced AP prognosis is poorbiologics Videllizumab is an alpha4 beta-7 classife inhibitor that has been approved for use in moderate and severe IBD, which has been reported to induce APother IBD treatmentsother methazole, glucocorticoids, and fat milk may induce pancreatitisif clearly related to IBD drug pancreatitis, should immediately stop the drug, according to emergency AP, chronic pancreatitis (CP) and other treatment, and closely observe the changes in the diseasethe clinical manifestations of respiratory tract injury caused by IBD-related respiratory damage IBD drugs, common symptoms include breathing difficulties, fever, cough, chest pain, peripheral blood ebinotic granulocytes, bronchoscopy osteophilia and pulmonary fibrosis, more likely to affect lung substance, if rapid lysation of respiratory symptoms after discontinuation is caused by drugsdrug clinical characteristics 5-amino salicylic acid preparation 5-aminosic salicylic acid preparation (including lysergic sulphate) is a commonly used drug of IBD, which causes less lung damage, most commonly causes interstitial pneumonia, can also cause acidophilic plesatis, acidosis cell pneumonia, capillary bronchitis and so on most medications show respiratory symptoms after 2 to 6 months, and symptoms are relieved after discontinuation immunosuppressants (1) thionine, 6-pyridine and cyclosporine are commonly used immunosuppressants for IBD, although lung damage caused by them is not common, but can cause direct, serious lung damage, and dose dependence, the drug within 1 month can also cause interstitial pneumonia, chronic pulmonary fibrosis, pulmonary edema and so on (2) methotrexate is a commonly used immunosuppressant of IBD, which can cause pneumonia, clinical manifestations of fever, peripheral haemophilia, etc., can also cause fatal lung damage, early lung abnormal ventilation dysfunction The lung damage caused by biological agents such as inflixi monoclonal antibodies and Adamu monoclonal antibodies, which biologics, is mainly opportunistic infection, and its pathogenesis is to inhibit the immune response mediated by T lymphocytes the most common tuberculosis, but also can cause spore disease and other infections such as cypores, psicombe, tissue cytoplasm disease, radiation bacteria disease, listeria disease, etc , rare acute respiratory distress syndrome, diffuse alveoli hemorrhage and interstitial pulmonary disease