Allergy: Happy cat smoking is not a dream, shovel officer allergic culprit found

As the saying goes, "suck a big mouthful of cats every day, easily live to ninety-nine", but looking at the milk in the arms of the kitten can not suck what kind of feeling, presumably only "cat hair allergy" shovel officer can experience.
may have had a "naive" idea of keeping a kitten without cat hair, but this is undoubtedly a great misunderstanding of the problem of cat allergies.
fact, cat hair is not the cause of allergies.
What causes our allergies is actually a tiny protein called FelD1, which is commonly found in the saliva, urine or peeling off dander of cats, and if not treated regularly, it can cause allergens to "fly all over the sky", so it is undoubtedly of great significance to explore effective treatments.
, bioallergen-specific immunotherapy (AIT) is a treatment that alters the natural course of allergic diseases through immunomodulation mechanisms.
, however, there are still many flaws in CAT-AIT today.
previous studies have shown that oligonucleotides (CpGs) have immunomodulation, so researchers are considering whether high doses of CpG oligonucleotides can be used to increase AIT's anti-inflammatory activity to fill gaps in ATI efficacy and safety.
recently, researchers at the Luxembourg Institute of Health published an article in the journal Allergy entitled "Comprehensive mapping of immune tolerances a regulatory TNFreceptor 2 signature in a murine model of successful Feld1-specificimmunotherapy" Using high-dose CpG adjuvant" article illustrates that high doses of the specific adjuvant molecule CpG oligonucleotides regulate the immune system's allergic reaction to the main cat allergen Feld 1, thereby promoting human tolerance to cat allergic reactions.
To study the clinical effects of bioallergen-specific immunotherapy (AIT) for high-dose CpG admissives, the researchers first constructed a MODEL of BALB/c OlaHsd mice allergic to Feld 1 and then evaluated the ability of humans to withstand the maximum dose of CpG without endotoxins.
Feld1-specific antibodies that detected serum in mice found that allergic mice treated with AIT showed lower IgE levels and higher IgA and IgG (anti-inflammatory) properties, and significant improvements in lung function and respiratory inflammation.
Subsequently, the researchers looked at cytokines in cytokines in bronchioblast dosing solution (BALF) and found that allergic cytokine levels decreased in AIT-treated allergic mice compared to untreated allergic mice.
suggests that in preclinical models of cat allergies, AIT therapy can reduce airway inflammation and reduce bronchial high reactivity.
, the researchers noted that AIT-treated mice had a large number of immune cells involved in allergic regulation and tolerance, such as plasma cell-like degenerative cells (pDC), natural killer cells (NKs), regulatory T cells (T-regs), and regulation. B-cells (B-regs), which express high levels of tumor necrotic factors (TNF-α) and tumor necrotic factors (TNFR-2), inhibit specific immune responses and act as a "brake" on the immune system.
more interesting, the researchers also found that AIT triggered the emergence of a new unique Treg, called biTreg, which balances the response of effect cells against the original.
this further demonstrates the reversibility of allergy characteristics and the anti-allergy effect of AIT.
to apply these results to the clinic, the researchers developed a subdern injection (sc) system based on Feld1/CpG therapy, mixing AIT solutions containing Feld1/CpG with trilayer copolymer hydrogels.
this route can reduce the number of eosinophils in the travenom, even more obvious than traditional abdominal drug (IP) effect, and can inhibit the Th2 type of immune response.
in summary, Feld1-specific AIT with high-dose CpG adulations can be successfully applied to hydrogel delivery systems and optimized in preclinical SC models for future use in conversion studies.
, the researchers optimized ATI-specific therapies for future cat hair allergies based on the largest dose of CpG that humans can withstand, and developed medically approved methods of dosing, laying the foundation for expanding new allergic immunotherapy.
believe that the future of the contemporary youth most yearning for life will be realized: people in bed, cats in their arms, hand milk tea, can not help themselves.
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