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Based on the core role of vitamin B in nucleotide synthesis and methylation, vitamin B is related to the risk and progression of colorectal cancer (CRC), but the correlation between vitamin B and the quality of life of patients with confirmed colorectal cancer is still Not currently.
This study aims to investigate whether the quality of life 6 months after the diagnosis of CRC is related to the following factors: 1) the blood concentration of B vitamins and related biomarkers within 6 months after diagnosis; 2) at the time of diagnosis and 6 months after diagnosis The changes in these concentrations between them; 3) B vitamin supplementation within 6 months after diagnosis; 4) Changes in the amount of B vitamin supplements within 6 months after diagnosis.
Enrolled 1676 newly diagnosed stage I-III colorectal cancer patients from 3 European cohorts.
The blood concentrations of 9 biomarkers related to vitamin B, folic acid, riboflavin, vitamin B6 and cobalamin were tested at the time of diagnosis and 6 months after diagnosis.
Information on the use of dietary supplements was also collected at these two time points.
Six months after diagnosis, the European Cancer Research and Treatment Organization Quality of Life Questionnaire was used to assess health-related quality of life.
At 6 months after diagnosis, higher pyridoxal 5'-phosphate (PLP) levels are associated with better physical, role and social function, and reduced fatigue.
In addition, the researchers also observed that doubling the ratio of hydroxykynurenine (a reverse marker of vitamin B6) is associated with a decline in global quality of life and physical function (β values of -3.
62 and -5.
01, respectively).
The dose-response relationship of vitamin B status shows a dose-response relationship between the level of pyridoxal 5'-phosphate and the quality of life.
In addition, no correlation was observed between the change in biomarker concentration between diagnosis and 6 months after diagnosis.
Subjects who stopped taking vitamin B supplements after the diagnosis reported that they were more fatigued than those who did not take vitamin B supplements.
In summary, higher vitamin B6 levels are associated with better quality of life in patients with CRC, but the correlation with the use of vitamin B supplements is limited.
Further research is needed to clarify the correlation between vitamin B and the quality of life of CRC patients.
Original source: Koole Janna L, Bours Martijn JL, Geijsen Anne JMR et al.
Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium.
Am J Clin Nutr , 2021, 10.
1093/ajcn/nqaa422.
This study aims to investigate whether the quality of life 6 months after the diagnosis of CRC is related to the following factors: 1) the blood concentration of B vitamins and related biomarkers within 6 months after diagnosis; 2) at the time of diagnosis and 6 months after diagnosis The changes in these concentrations between them; 3) B vitamin supplementation within 6 months after diagnosis; 4) Changes in the amount of B vitamin supplements within 6 months after diagnosis.
Enrolled 1676 newly diagnosed stage I-III colorectal cancer patients from 3 European cohorts.
The blood concentrations of 9 biomarkers related to vitamin B, folic acid, riboflavin, vitamin B6 and cobalamin were tested at the time of diagnosis and 6 months after diagnosis.
Information on the use of dietary supplements was also collected at these two time points.
Six months after diagnosis, the European Cancer Research and Treatment Organization Quality of Life Questionnaire was used to assess health-related quality of life.
At 6 months after diagnosis, higher pyridoxal 5'-phosphate (PLP) levels are associated with better physical, role and social function, and reduced fatigue.
In addition, the researchers also observed that doubling the ratio of hydroxykynurenine (a reverse marker of vitamin B6) is associated with a decline in global quality of life and physical function (β values of -3.
62 and -5.
01, respectively).
The dose-response relationship of vitamin B status shows a dose-response relationship between the level of pyridoxal 5'-phosphate and the quality of life.
In addition, no correlation was observed between the change in biomarker concentration between diagnosis and 6 months after diagnosis.
Subjects who stopped taking vitamin B supplements after the diagnosis reported that they were more fatigued than those who did not take vitamin B supplements.
In summary, higher vitamin B6 levels are associated with better quality of life in patients with CRC, but the correlation with the use of vitamin B supplements is limited.
Further research is needed to clarify the correlation between vitamin B and the quality of life of CRC patients.
Original source: Koole Janna L, Bours Martijn JL, Geijsen Anne JMR et al.
Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium.
Am J Clin Nutr , 2021, 10.
1093/ajcn/nqaa422.
