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Relative adrenal insufficiency (RAI) is associated with poor prognosis in adult patients with cirrhosis
.
But so far, there is no research on the correlation between RAI and the prognosis of children with liver cirrhosis
.
Children explore the incidence of RAI in children with decompensated liver cirrhosis and its impact on the clinical prognosis of children
On day 1 and day 21, hemodynamically stable children with decompensated liver cirrhosis were sampled with serum basal cortisol and peak cortisol (30 minutes after intravenous injection of 1 μg tetracorticotropin)
.
RAI diagnostic criteria: peak cortisol <500 nmol/L
.
diagnosis
Complications and mortality in children with or without RAI
Complications and mortality in children with or without RAIA total of 63 children (age 128 ± 48 months, 78% boys) were recruited
.
At baseline and on day 21, the incidence of RAI was 54% and 61%, respectively
.
At baseline and on day 21, the incidence of RAI was 54% and 61%, respectively
Predictive scores of different models for follow-up complications
Predictive scores of different models for follow-up complicationsThe PELD-delta cortisol model (area under the curve 0.
84, p<0.
001; sensitivity 92%, specificity 60%) can predict the incidence of complications better than pure PELD or Child-Turcotte-Pugh score
.
84, p<0.
001; sensitivity 92%, specificity 60%) can predict the incidence of complications better than pure PELD or Child-Turcotte-Pugh score
.
The PELD-delta cortisol model (area under the curve 0.
84, p<0.
Relative adrenal insufficiency (RAI) is a risk factor for complications of cirrhosis in children during short-term follow-up Relative adrenal insufficiency (RAI) is a risk factor for complications of cirrhosis in children during short-term follow-up
Original source:
Original source:Tripathi Parijat Ram,Sen Sarma Moinak,Yachha Surender Kumar et al.
Relative Adrenal Insufficiency in Decompensated Cirrhotic Children: Does It Affect Outcome? Leave a message here
