Ann Hematol: Acute graft-versus-host disease increases the risk and accuracy of predictive models for transplant-associated thrombotic microangiopathy in patients with myelodysplastic syndromes

Allogeneic hematopoietic stem cell transplantation (HSCT) is the only treatment option for patients with MDS
.

Despite significant improvements in transplant practice, a transplant-related complication, transplant-associated thrombotic microangiopathy ( TA-TMA), remains a cause of post-transplant death

Allogeneic hematopoietic stem cell transplantation (HSCT) is the only treatment option for patients with MDS

This study assessed risk factors for TA-TMA and developed a predictive model for this complication

Figure 1: Multivariate analysis of MDS patients with TA-TMA

Figure 1: Multivariate analysis of MDS patients with TA-TMA

Figure 2: Hazard ratio forest plot of different risk factors for overall survival in patients with MDS
.

Cox regression model (***p<0.

Figure 2: Hazard ratio forest plot of different risk factors for overall survival in patients with MDS

TA-TMA grade was associated with a more than twofold increased risk of death (HR 2.

Figure 3: Forest plot of odds ratios of different risk factors for TA-TMA in MDS patients after HSCT
.

Logistic regression model (*p<0.

Figure 3: Forest plot of odds ratios of different risk factors for TA-TMA in MDS patients after HSCT

Figure 4: Texture feature selection using least absolute shrinkage and selection operator (lasso) binary logistic regression model

Figure 4: Texture feature selection using least absolute shrinkage and selection operator (lasso) binary logistic regression model

Next, the research team put these two variants and the other three variants into the predictive model via multivariate Lasso regression
.

To quantify the contribution of each factor, a nomogram (C-index of 0.

Next, the research team put these two variants and the other three variants into the predictive model via multivariate Lasso regression

Figure 5: Nomogram for risk assessment of TA-TMA in patients with MDS and its predictive performance

Figure 5: Nomogram for risk assessment of TA-TMA in patients with MDS and its predictive performance

This real-world study demonstrates the prognostic value of hemostatic disorders in patients undergoing HSCT
.

In conclusion, the findings show that TA-TMA predicts worse OS in patients with MDS after receiving allogeneic hematopoietic stem cell transplantation

This real-world study demonstrates the prognostic value of hemostatic disorders in patients undergoing HSCT
.
In conclusion, the findings show that TA-TMA predicts worse OS in patients with MDS after receiving allogeneic hematopoietic stem cell transplantation
.
A cross-validated multivariate score, including grade III-IV aGVHD, showed good agreement between TA-TMA grading and predicting long-term prognosis in MDS after HSCT
.
allogeneic hematopoietic stem cell transplantation

 

Original source:

Original source:

Zhang, Z.
, Wang, H.
, Qi, J.
et al.
 Acute graft-versus-host disease increase risk and accuracy in prediction model of transplantation-associated thrombotic microangiopathy in patients with myelodysplastic syndrome.
  Ann Hematol  (2022).
https ://doi.
org/10.
1007/s00277-022-04820-z

Zhang, Z.
, Wang, H.
, Qi, J.
  et al.
 Acute graft-versus-host disease increase risk and accuracy in prediction model of transplantation-associated thrombotic microangiopathy in patients with myelodysplastic syndrome.
  Ann Hematol  (2022).
https ://doi.
org/10.
1007/s00277-022-04820-z Zhang, Z.
, Wang, H.
, Qi, J.
  et al.
 Acute graft-versus-host disease increase risk and accuracy in prediction model of transplantation- associated thrombotic microangiopathy in patients with myelodysplastic syndrome.
  Ann Hematol  (2022).
https://doi.
org/10.
1007/s00277-022-04820-z et al.
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