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    Home > Active Ingredient News > Blood System >  Ann Hematol: Daily oral iron supplementation versus alternate-day therapy in women of reproductive age with iron deficiency anemia

     Ann Hematol: Daily oral iron supplementation versus alternate-day therapy in women of reproductive age with iron deficiency anemia

    • Last Update: 2022-05-25
    • Source: Internet
    • Author: User
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    Iron deficiency anemia (IDA) is considered the most common cause of anemia in the world
    .
    The main goal of iron replacement therapy is to normalize hemoglobin levels and replenish iron stores
    .
    Current guidelines for the treatment of iron deficiency recommend daily divided doses of iron to increase absorption
    .
    Hepcidin is a key regulator of systemic iron homeostasis, coordinating with intracellular iron metabolism
    .
    Daily and fractionated dosing may increase serum hepcidin and decrease iron absorption
    .

    Iron deficiency anemia (IDA) is considered the most common cause of anemia in the world
    .
    The main goal of iron replacement therapy is to normalize hemoglobin levels and replenish iron stores
    .
    Current guidelines for the treatment of iron deficiency recommend daily divided doses of iron to increase absorption
    .
    Hepcidin is a key regulator of systemic iron homeostasis, coordinating with intracellular iron metabolism
    .
    Daily and fractionated dosing may increase serum hepcidin and decrease iron absorption
    .

    In this study, we aimed to compare the effectiveness of daily and every other day oral iron replacement therapy for iron-deficiency anemia in women of reproductive age
    .
    The research team
    included premenopausal women aged 18 to 50 with iron-deficiency anemia
    .
    Forty patients were treated with oral iron at a daily dose of 2*80 mg (iron sulfate)

    .
    Forty-three patients were treated with iron at doses of 2*80 mg (ferric sulfate) every other day
    .

    In this study, we aimed to compare the effectiveness of daily and every other day oral iron replacement therapy for iron-deficiency anemia in women of reproductive age
    .
    The research team
    The research team included premenopausal women aged 18 to 50 with iron deficiency anemia
    .
    Forty patients were treated with oral iron at a daily dose of 2*80 mg (iron sulfate)

    .
    Forty-three patients were treated with iron at doses of 2*80 mg (ferric sulfate) every other day
    .

    Figure: Trends of hemoglobin (A), ferritin (B) and heparin (C) values ​​in groups 1 and 2

    Figure: Trends of hemoglobin (A), ferritin (B) and heparin (C) values ​​in groups 1 and 2

    After 2 months of oral iron treatment, hemoglobin, mean corpuscular volume, serum iron, total iron-binding capacity, and transferrin saturation were significantly improved in both groups
    .
    Hemoglobin, serum iron, transferrin saturation, and ferritin values ​​were significantly elevated at the end of treatment in both groups
    .
    Although the median hepcidin level measured on day 15 was higher in the alternate-day treatment group than in the daily treatment group, there was no significant difference
    .

    After 2 months of oral iron treatment, hemoglobin, mean corpuscular volume, serum iron, total iron-binding capacity, and transferrin saturation were significantly improved in both groups
    .
    Hemoglobin, serum iron, transferrin saturation, and ferritin values ​​were significantly elevated at the end of treatment in both groups
    .
    Although the median hepcidin level measured on day 15 was higher in the alternate-day treatment group than in the daily treatment group, there was no significant difference
    .

    Current guidelines for the treatment of iron defense recommend administration of daily divided doses of iron to increase absorption
    .
    However, with daily divided doses, serum heparin may increase, thereby reducing iron absorption in subsequent doses

    .
    Iron supplementation significantly increases heparin, but the duration and magnitude of the increase, the dose dependence, and the effect on subsequent iron absorption are unknown

    .
    Looking at the effects of two different treatment regimens on anemia, iron defenses and heparin levels, the research team believes that
    patient adherence to treatment could be improved by providing treatment every other day instead of every day , a gastroenterological side effect of discontinuing iron therapy A common cause of AD that can be prevented with AD treatment without compromising the efficacy of treatment
    .

    Current guidelines for the treatment of iron defense recommend administration of daily divided doses of iron to increase absorption
    .
    However, with daily divided doses, serum heparin may increase, thereby reducing iron absorption in subsequent doses

    .
    Iron supplementation significantly increases heparin, but the duration and magnitude of the increase, the dose dependence, and the effect on subsequent iron absorption are unknown

    .
    Looking at the effects of two different treatment regimens on anemia, iron defenses and heparin levels, the research team believes that
    patient adherence to treatment could be improved by providing treatment every other day instead of every day , a gastroenterological side effect of discontinuing iron therapy A common cause of AD that can be prevented with AD treatment without compromising the efficacy of treatment
    .
    Provide treatment every other day instead of every day to improve patient adherence to treatment

     

    Original source:

    Original source:

    Kaynar, LA, Gökçen, S.
    , Can, F.
     
    et al.
     Comparison of daily oral iron replacement therapy with every other day treatment in female reproductive age patients with iron-deficiency anemia.
     
    Ann Hematol  (2022).
    https://doi .
    org/10.
    1007/s00277-022-04835-6

    Kaynar, LA, Gökçen, S.
    , Can, F.
     
    et al.
     Comparison of daily oral iron replacement therapy with every other day treatment in female reproductive age patients with iron-deficiency anemia.
     
    Ann Hematol  (2022).
    https://doi .
    org/10.
    1007/s00277-022-04835-6
    Kaynar, LA, Gökçen, S.
    , Can, F.
     
    et al.
     Comparison of daily oral iron replacement therapy with every other day treatment in female reproductive age patients with iron-deficiency anemia .
     
    Ann Hematol  (2022).
    https://doi.
    org/10.
    1007/s00277-022-04835-6
    et al.
    Ann Hematol commented

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