Ann Hematol: Gut microbiota score predicts survival after allogeneic hematopoietic stem cell transplantation

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a treatment option for hematological malignancies
.

In addition to malignancy recurrence, complications such as graft-versus-host disease (GVHD) and infection remain the leading causes of death, limiting the application of allo-HSCT

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a treatment option for hematological malignancies

In this study, a research team prospectively obtained stool samples from patients undergoing allo-HSCT on day 15±1 post-transplantation, from 209 patients at two centers

Figure 1: Schematic diagram of patients participating in this study

Figure 1: Schematic diagram of patients participating in this study

Figure 2: Four bacterial taxa selected for microbiota diversity and predicted survival
.

Diversity and ROC curves of different bacteria at day 15 post-transplantation were used to predict survival

Figure 2: Four bacterial taxa selected for microbiota diversity and predicted survival

Figure 3: Differences in microbiota abundance and composition at day 15 post-transplantation between groups
.

A Heat map of bacterial abundance in each group of patients

Figure 3: Differences in microbiota abundance and composition at day 15 post-transplantation between groups

Compared with high scores, low scores were associated with better 3-year cumulative overall survival (OS) and lower mortality (88.

Figure 4: Cumulative gut microbiota (AIM) scores and their association with survival
.

The 3-year cumulative overall survival (OS, A ) and disease-free survival (DFS, B ) of the low group were longer than those of the high group

Figure 4: Cumulative gut microbiota (AIM) scores and their association with survival

Figure 5: Cumulative gut microbiota (AIM) scores predict survival
.

AIM score, cumulative gut microbiota score; AUC, area under receiver operating characteristic curve; ROC, receiver operating characteristic curve

Figure 5: Cumulative gut microbiota (AIM) scores predict survival

This study shows that gut microbiota scores can predict survival after allo-HSCT
.
Research data can guide clinicians in identifying patients at risk for serious mortality
.
In addition, these patients should consider and implement interventions to restore gut microbiota integrity, such as fecal microbiota transplantation or pre-emptive treatment strategies
.
These patients should consider and implement interventions to restore gut microbiota integrity, such as fecal microbiota transplantation or pre-emptive treatment strategies
.

Future studies will need to investigate the mechanisms by which the microbiota disrupts outcomes in greater depth, and larger prospective validation studies from multiple centers will be essential in the future
.

Future studies will need to investigate the mechanisms by which the microbiota disrupts outcomes in greater depth, and larger prospective validation studies from multiple centers will be essential in the future
.

 

Original source:

Original source:

Han, L.
, Zhang, H.
, Ma, P.
et al.
 Intestinal microbiota score could predict survival following allogeneic hematopoietic stem cell transplantation.
  Ann Hematol  (2022).

Han, L.
, Zhang, H.
, Ma, P.
  et al.
 Intestinal microbiota score could predict survival following allogeneic hematopoietic stem cell transplantation.
  Ann Hematol  (2022).
et al.
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