Ann Hematol: The efficacy of oral iron therapy for iron deficiency anemia twice a day VS the next day.

A recent study of iron-deficing women challenged the current daily oral iron treatment for iron deficiency anemia (IDA).
day-to-day drug use promotes more iron absorption.
in this randomized controlled trial, we looked at the efficacy and safety of oral iron therapy for severe IDA the next day (AD) and twice a day (BD), and the results were published online in Ann Hematol.
results, a total of 62 patients were randomly grouped, 31 patients in the BD group received 60 mg of element iron twice a day, and 31 patients in the AD group received 120 mg of iron the next day.
BD patients reached the primary endpoint of 2g/dl at 3 weeks (32.3% vs. 6.5%, p .lt;0.0001) and 6 weeks (58% vs. 35.5%, p . 0.001).
the BD group increased significantly in 3 weeks (1.6 vs. 1.1, p s 0.02) and 6 weeks (2.9 vs. 2.0 g/dl, p s 0.03).
, there was no significant difference between the increase in mesoglobin in the AD group at 6 weeks and the BD group at 3 weeks.
the same amount of iron as the next day for six weeks and twice a day for three weeks.
reported more nausea in patients in the BD group (P - 0.03).
in summary, the choice of oral iron treatment twice a day or the next day should depend on the severity of anemia, the rapid response required, and the patient's preference for either option due to adverse events.
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