Ann Rheum Dis: The Zheng Houfeng team at Westlake University sheds light on the relationship between psoriasis arthritis and osteoporosis.

On August 1st, Beijing time, the Rheumatology Yearbook (IF-16.102) was published online under the title "Systemic evaluation of the relationship" and "psoriasis, p A research paper on soriatic arthritis and osteoporosis: observational and mendelian randomization study illustrates the relationship between psoriasis (commonly known as psoriasis) and psoriasis arthritis and osteoporosis.
Zheng Houfeng of the School of Life Sciences, West Lake University, China, is the first author of this newsletter, and Xia Jiangwei, a 2018 doctoral student, is the first author.
independent communications unit working on the study at Westlake University in New York.
participating organizations include the University of Michigan, Zhejiang Ii Hospital, Binzhou Medical College and Jiangxi Medical College.
University's Super-Computing Center also provides technical support for the project.
why do you study the relationship between skin disease and osteoporosis? Zheng Houfeng was a dermatologist, in the M.D. research topic is around the genetic research of psoriasis, in Canada McGill University postdoctoral period, Zheng Houfeng turned to bone metabolic correlation genetic research, so the two diseases are more understanding.
psoriasis is a common autoimmune skin disease, with a incidence rate of 2.5% in the European population and 0.1%-0.5% in the Asian population, the most serious complication of which is psoriasis arthritis.
Although there have been many studies in the past that have focused on the relationship between psoriasis and osteoporosis, many studies have been inconsistent due to potential mixing factors, or the inability to collect sufficient data in its entireity, leading to the current debate about whether psoriasis can lead to osteoporosis.
the 2017 British Journal of Dermatology, "Psoriasis andosteoporosis: The Debate Continues."
determine whether there is an attribution relationship between psoriasis and osteoporosis has attracted more and more researchers' attention, it has also become an important clinical issue.
so Zheng Houfeng's team analyzed the relationship between the two in a more comprehensive way on the basis of big data, and came to reliable conclusions, providing new evidence for clinical guidelines.
their study found that patients with Psoriatic arthritis had significantly fewer bone mass than the control group, but the association was not determined by genetic factors, i.e. there was no attribution.
they speculate that secondary hair may cause osteoporosis (e.g. by taking medication or lack of exercise).
To prove this, they included factors in the use of drugs and physical activity in patients with psoriasis arthritis, and through mediation analysis," they found that 63% of the risk effects of psoriasis on reducing bone density were indirectly mediated by taking drugs (methotrexate, cyclosporine), while the intermediary effect of physical exercise was 8%.
based on non-attribution hypothesis, non-arthritis psoriasis patients do not have secondary effects and are not potential risk factors for bone reduction or osteoporosis.
addition, they found that men with psoriasis arthritis had higher significant low bone mass characteristics than women in the control group.
they speculated that the likely cause was that most of the women included in the study were post-menopaid women, and that a lack of estrogen may have a greater effect on bone density than psoriasis arthritis.
summary of Zheng's team's findings is that, first, there is no attribution relationship between psoriasis (including arthritis) and osteoporosis.
However, psoriasis arthritis, as a heavy-duty psoriasis, is treated clinically with drugs such as methotrexate or cyclosporine that may affect bone reconstruction, leading to osteoporosis.
Previous observational studies cannot be verified by each other, possibly because: (1) the inclusion of psoriasis patients did not sub-type disease, such as psoriasis arthritis patients did not have a separate analysis, (2) the inclusion of disease mix factors did not include drug treatment.
it is important to stress that this study was a cross-sectional observational study of 432,513 sample data included in the UK's large sample database (UK Biobank), at which there was sufficient statistical certainty to study the relationship between exposure and outcome.
For clinical applications, Zheng's team recommends that patients with psoriasis-pathogenic arthritis, especially those treated with methotrexate or cyclosporine, be regularly screened for reduced bone mass and the risk of osteoporosis, and that appropriate health management be provided to reduce the risk of fractures.
Funding Information The research was supported by the National Overseas High-Level Talent Introduction Program (Youth Project), the National Natural Science Foundation of China (81871831), and the Zhejiang Natural Science Foundation Outstanding Youth Project (LR17H070001), and the West Lake University Talent Introduction Special Fund.
.