Antioxidants: the antioxidant properties of serum albumin and the burden of glucose oxidative damage in patients with or without coronary heart disease with or without type 2 diabetes

Background: Type 2 diabetes mellitus (T2DM) is associated

RAGE is a multiligand member of the cell surface molecule Ig superfamily that binds to AGE and induces cell signaling, including activation of nuclear factor κB (NF-κB), increased expression of cytokines and adherent molecules, induction of oxidative stress, and increase

Human serum albumin (HSA) is the most abundant circulating protein and has important antioxidant activity by capturing free radicals

Objective: The purpose of this study was to verify for the first time the different burdens

Methods: In this study, we assessed the presence

Results: T2DM patients with and without coronary heart disease had significantly higher

Figure 1 Clinical and metabolic data of four groups of participants were evaluated

Table 1

Figure 2 Assessing the saccharification and oxidation parameters

Figure 3: Scatterplot of the variables with the greatest correlation between the variables reported in Supplementary Table S2

Figure 4: Albumin isomers and functional effects

Conclusion: These findings suggest that albumin mass and the steady-state balance between sugar oxidation and thiolization may have an impact on

Piarulli F, Banfi C, Brioschi M, et al.