AP&T: Collagen Types I, III, and IV-Associated Serological Markers Associated with Disease Progression in Stenotic and Penetrating Crohn's Disease

Crohn's disease (CD) is a chronic inflammatory bowel disease primarily affecting the gastrointestinal (GI) tract, and the major pathogenesis may be related to the gut microbiome of genetically predisposed individual.

We collected serum samples from 101 CD patients with type III/IV collagen formation (PRO-C3, PRO-C4) and matrix metalloproteinase (MMP) or granzyme-B (GrzB)-mediated I, III , IV and VI collagen degradation products were C1M, C3M, C4M, C4G, C6Ma3. Among the 101 CD patients, Montreal type was B1: n = 37; B2: n = 27; B3: n = 37), and 96 healthy controls were also included in this stud.

Study results showed that C1M, C3M and C4M were significantly reduced in patients with stenotic disease (Montreal B2) and could well differentiate patients with non-stenotic, non-penetrating (B1) or penetrating (B3) disease (p<001.

The present study demonstrates that increased degradation products of collagen types I, III, and IV and over-formation of collagen IV are strongly associated with narrow C.

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