AP-T: Regular use of proton pump inhibitors and the risk of rheumatoid arthritis in women.

!---- background proton pump inhibitors (PPI) have a significant impact on the gut microbiome, which in turn may increase the risk of rheumatoid arthritis (RA)study aims to assess the risk of regular use of PPI and RAMethod sourf of U.Snurses, exposed to PPI that has been used regularly over the past two yearsRA's diagnosis is done by definition by the U.SMedical Insurance Administrationthe researchers estimated the risk ratio (HRs) and the confidence interval (CIs) by adjusting the time-dependent Cox regression of potential confounding factorsresults This study recorded 421 ra patients with follow-up time of more than 1753879 yearshad a 44% higher RA risk for regular PPI users than non-conventional users (adjusted HR s 1.44; 95% CI, 1.10-1.89)The risk ofRA increases with the total duration of use of PPI (P trend s 0.008)1.22 (95% CI, 0.93-1.62) for women who used the corrected HR for 4 years compared to non-conventional users and 1.73 (95% CI, 1.14 to 2.61) for women who used it for 4 yearsconcluded that regular use of PPI was associated with an increased risk of RA in women, with higher risk observed in individuals who used PPI for a longer duration.