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Metabolic-related fatty liver disease (MAFLD) is now the most common cause of chronic liver disease worldwide, with an estimated global prevalence rate of 25%.
the incidence of MAFLD, which includes simple fat degeneration to non-alcoholic fatty hepatitis (NASH) and cirrhosis, is associated with an increase in the global incidence of type 2 diabetes (T2DM) and obesity.
people with MAFLD also have a high risk of metabolic complications, including central obesity, insulin resistance and cardiovascular disease (CVD), and lifestyle interventions are still the cornerstone of treatment for MAFLD in the absence of special drugs.
is known to treat and prevent many chronic inflammatory diseases, such as cancer, T2DM, arthritis and CVD.
the main purpose of this study was to determine the effects of individual exercise on histological endpoints in MAFLD patients, in particular the improvement of the disease through moderate to intense aerobic exercise over a 12-week scale.
12 weeks of aerobic exercise interventions for patients who had been biopsy-proven to be MAFLD.
4 patients completed exercise intervention (exercise group n s 16, control group n s 8).
In the exercise group, aerobic exercise for 12 weeks reduced fibrosis by one level in 58% (P-0.034) and 67% (P-0.020) patients, but had no effect on fat degeneration (P-1.000), small-leaf inflammation (P=0.739) or NAFLD activity score (P=0.172).
, VmaxO2max increased by 17% compared to the control group, but this improvement level was not maintained for 12 or 52 weeks after intervention.
patients with fibrosis and balloon improvement had VmaxO2max of 25% (P=0.020) and 26% (P=0.010), respectively.
weight (P-0.038), waist circumference (P-0.015) and fat mass (P-0.007) were all significantly reduced in patients in the exercise group, but no patients lost 7% to 10% of their body weight.
study sheds light on the benefits of 12 weeks of aerobic exercise interventions in improving the histological endpoint of MAFLD.
, long-term aerobic exercise should be performed in patients with MAFLD.
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