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ARD: Behçet's disease risk variant HLA-B51/ERAP1-Hap10 alters human CD8 T-cell immunity

 Last Update: 2022-09-06
 Source: Internet
 Author: User

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OBJECTIVE: The endoplasmic reticulum (ERAP1) haplotype Hap10 encodes an endoplasmic reticulum (ER) resident peptide trimming allotype of the aminopeptidase ERAP1 with low enzymatic activity

Methods: We genotyped and immunophenotyped 26 untreated Turkish BD subjects and 22 healthy donors to generate CRISPR-Cas9 ^ERAP1 knockout cells (KO ), analyzed peptide length differences of HLA class I-binding peptide sets and assessed the immunogenicity of genome-edited cells in a CD8 T cell co-culture system

RESULTS: The allele frequencies of ERAP1-Hap10 were similar to previous studies

Conclusions: This study demonstrates that low activity ERAP1 alters immunogenicity to CD8 T cells, mediated by an HLA class I peptide set with under-trimmed peptides

Credit: Cavers A, Kugler MC, Ozguler Y, Al-Obeidi AF, Hatemi G, Ueberheide BM, Ucar D, Manches O, Nowatzky J.

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