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ARD: Genome sequencing and functional analysis to identify MAP4K3/GLK germline and somatic mutations associated with systemic lupus erythematosus

 Last Update: 2021-10-20
 Source: Internet
 Author: User

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Overexpression of MAP4K3 (GLK) in

in conclusion:

Conclusion: Conclusion:

Multiple GLK germline and somatic mutations in SLE patients induce GLK overexpression by increasing mRNA or protein stability .

Source:

Chuang HC, Hung WT, Chen YM, Hsu PM, Yen JH, Lan JL, Tan TH.

Chuang HC, Hung WT, Chen YM, Hsu PM, Yen JH, Lan JL, Tan TH.
Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus.
Ann Rheum Dis.
2021 Oct 5: annrheumdis- 2021-221010.
doi: 10.
1136/annrheumdis-2021-221010.
Epub ahead of print.
PMID: 34610951.

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