ARD: Induced antibodies to the angiotensin receptor type 1 trigger cross-species skin and lung inflammation and dermal fibrosis

Objective: Angiotensin receptor type 1 (AT1R, AGTR1) is a G protein-coupled receptor (GPCR) that is mainly involved in the regulation of vascular tone, vascular smooth muscle cell proliferation, extracellular matrix production and inflammatio.

Objective: Objective: Angiotensin receptor type 1 (AT1R, AGTR1) is a G protein-coupled receptor (GPCR) , which is mainly involved in the regulation of vascular tone, vascular smooth muscle cell proliferation, extracellular matrix production and inflammatio.

Methods: Methods: C57BL/6J mice were immunized with membrane-embedded human AT1R or empty membranes as control.

Results: Results: AT1R -immunized mice developed perivascular skin and lung inflammation, lymphocytic alveolitis, weak lung endothelial cell apoptosis, and skin fibrosis with Smad2/3 signaling, in control or in the absence of CD4+ T and B The above pathological phenomenon does not exist in the mice with cel.

Conclusion: Conclusion: The immunization strategy of this study successfully induces AT1R Abs , which promote inflammation by activating AT1R , and may lead to fibrosi.

Source:

Source:

Yue X, Yin J, Wang X , et a.

Yue X, Yin J, Wang X , et a.
Induced antibodies directed to the angiotensin receptor type 1 provoke skin and lung inflammation, dermal fibrosis and act species overarchi.
Annals of the Rheumatic DiseasesPublished Online First: 20 May 202 doi: 11136 /annrheumdis-2021-222088 , et al Annals of the Rheumatic Diseasesleave a message here