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OBJECTIVE: To clarify the factors predicting axial spondyloarthritis (axSpA) in first-degree relatives of patients with ankylosing spondylitis (AS) .
We investigated the predictive value of HLA-B27 and radiographic sacroiliitis status in the proband for the occurrence of FDR disease and also assessed the predictive value of clinical history characteristics in first-degree relatives, including chronic inflammatory back pain ( CIBP) and acute anterior uveitis (AAU) , and how they can be used to improve the classification and diagnosis of axSpA .
We investigated the predictive value of HLA-B27 and radiographic sacroiliitis status in the proband for the occurrence of FDR disease and also assessed the predictive value of clinical history characteristics in first-degree relatives, including chronic inflammatory back pain ( CIBP) and acute anterior uveitis (AAU) , and how they can be used to improve the classification and diagnosis of axSpA .
Methods: In 1985 , investigators studied 363 AS probands and 806 first-degree relatives who underwent rheumatological examination, completed questionnaires, provided blood samples for HLA typing, and underwent sacroiliac X- rays of the joints .
At the 2018-2019 follow-up, 125 patients and 360 first-degree relatives were available for study and completed a mailed questionnaire on axSpA characteristics .
First- degree relatives were asked to report whether they were diagnosed with axSpA by Swiss rheumatologists after 1985 .Methods: In 1985 , investigators studied 363 AS probands and 806 first-degree relatives who underwent rheumatological examination, completed questionnaires, provided blood samples for HLA typing, and underwent sacroiliac X- rays of the joints .
At the 2018-2019 follow-up, 125 patients and 360 first-degree relatives were available for study and completed a mailed questionnaire on axSpA characteristics .
First- degree relatives were asked to report whether they were diagnosed with axSpA by Swiss rheumatologists after 1985 .
RESULTS: In HLA-B27(+) FDR , axSpA occurred in 25.
4% – 26.
3% , independent of the proband's radiographic sacroiliitis status
RESULTS: In HLA-B27(+) FDR , axSpA occurred in 25.
4% – 26.
3% , independent of the proband's radiographic sacroiliitis status
Conclusion: Acute anterior uveitis in first-degree relatives of probands with axial spondyloarthritis should prompt screening for axial spondyloarthritis
Source: van der Linden SM, Khan MA, Li Z , et al.
Factors predicting axial spondyloarthritis among first-degree relatives of probands with ankylosing spondylitis: a family study spanning 35 years.
Annals of the Rheumatic Diseases Published Online First: 11 March 2022 .
van der Linden SM, Khan MA, Li Z , et al.
, et al.
Factors predicting axial spondyloarthritis among first-degree relatives of probands with ankylosing spondylitis: a family study spanning 35 years.
Annals of the Rheumatic Diseases Annals of the Rheumatic Diseases Published Online First: 11 March 2022.
doi: 10.
1136/annrheumdis-2021-222083 Leave a comment here
