Arthritis & Rheumatology: China's genome-wide association study identifies new risk sites for Behcet's disease uveitis

Purpose : Behcet's disease (BD) is a systemic inflammatory disease, usually manifested as recurrent oral and genital ulcers, uveitis, skin damage, and even inflammation of the nerve and gastrointestinal system
.

This study explores the susceptibility sites associated with Behcet's disease ( BD ) uveitis

ObjectiveObjective : Behcet's disease (BD) is a systemic inflammatory disease, usually presents with recurrent oral and genital ulcers, uveitis, skin lesions, neurological and gastrointestinal systems and even inflammation

Methods : Researchers from the National Eye Center and a number of Chongqing Medical University / Hospital collaborators conducted a genome-wide association study (GWAS) , including 978 Ming BD uveitis cases and 4388 control subjects and population in China of 953 Ming BD uveitis cases and 2129 controls were carried out replication studies
.

GWAS genotyping uses Illumina Human Omni ZhongHua-8 chip

MethodsMethods : Researchers from the National Eye Center and a number of Chongqing Medical University / Hospital collaborators conducted a genome-wide association study (GWAS) , including 978 Ming BD uveitis cases and 4388 control subjects and population in China in for 953 Ming BD uveitis cases and 2129 controls were carried out replication studies

ResultsResults : In the BD identified genome-wide association uveitis three separate HLA alleles ( HLA-B51 , HLA-A26 and HLA-C0704 )

ConclusionConclusion : The GWAS study identified a new set of genetic variations, these variations with BD -related susceptibility to uveitis

Source:

Source:

Su G, Zhong Z, Zhou Q, Du L, Ye Z, Li F, Zhuang W, Wang C, Liang L, Ji Y, Cao Q, Wang Q, Chang R, Tan H, Yi S, Li Y, Feng X , Liao W, Zhang W, Shu J, Tan S, Xu J, Pan S, Li H, Shi J, Chen Z, Zhu Y, Ye X, Tan X, Zhang J, Liu Z, Huang F, Yuan G, Pang T, Liu Y, Ding J, Gao Y, Zhang M, Chi W, Liu X, Wang Y, Chen L, Meguro A, Takeuchi M, Mizuki N, Ohno S, Zuo X, Kijlstra A, Yang P.

A genome- wide association study in Chinese identifies novel risk loci for Behcet's uveitis.
Arthritis Rheumatol.
2021 Oct 15.

Su G, Zhong Z, Zhou Q, Du L, Ye Z, Li F, Zhuang W, Wang C, Liang L, Ji Y, Cao Q, Wang Q, Chang R, Tan H, Yi S, Li Y, Feng X , Liao W, Zhang W, Shu J, Tan S, Xu J, Pan S, Li H, Shi J, Chen Z, Zhu Y, Ye X, Tan X, Zhang J, Liu Z, Huang F, Yuan G, Pang T, Liu Y, Ding J, Gao Y, Zhang M, Chi W, Liu X, Wang Y, Chen L, Meguro A, Takeuchi M, Mizuki N, Ohno S, Zuo X, Kijlstra A, Yang P.
A genome- wide association study in Chinese identifies novel risk loci for Behcet's uveitis.
Arthritis Rheumatol.
2021 Oct 15.
doi: 10.
1002/art.
41998.
Epub ahead of print.
PMID: 34652073.
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