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The innovation point is based on the ceria nanoenzyme designed a mast cell nano stabilizer with phosphatase-like activity, which can continuously regulate the phosphate signal cascade related to degranulation in the mast cell by using the reproducible oxygen vacancies on the surface.
Long-term prevention of allergic diseases.
Key words cerium oxide nanoenzyme, phosphatase-like activity, mast cells, treatment time window, allergic disease prevention More than 25% of people worldwide suffer from a variety of allergic diseases, including asthma, rhinitis, food allergies, etc.
However, about 90% of patients are not well treated, which brings unbearable pain and economic burden to patients.
Allergic disease is a pathological immune response that involves a series of immune cells.
Among them, mast cells are the main effector cells.
When stimulated by an allergen, mast cells will activate the phosphate signal cascade in the cell to cause a series of "domino effects", including the production of reactive oxygen species (ROS), degranulation, release of allergic mediators, and pathological reactions, which can cause allergies.
The occurrence of sexual diseases.
Currently, antihistamines, steroids and non-steroidal anti-inflammatory drugs are commonly used clinically to treat allergic diseases.
However, these drugs can only relieve pathological symptoms and cannot prevent the occurrence of allergic diseases.
Mast cell stabilizers can inhibit the degranulation of mast cells and release inflammatory mediators, which is expected to prevent the occurrence of allergic diseases.
However, most small molecule mast cell stabilizers (including the gold standard cromolyn disodium) have a narrow treatment time window, and patients with allergic constitution often miss the optimal administration time of mast cell stabilizers.
Therefore, the development of mast cell stabilizers with a long therapeutic time window is essential for the prevention of allergic diseases.
Professor Li Fangyuan of Zhejiang University, Professor Wei Jifu of Nanjing Medical University, and Professor Ling Daishun of Shanghai Jiaotong University prepared a cerium oxide nanozyme with phosphatase-like activity in response to this problem and designed it as a mast cell nano stabilizer for use Long-term prevention of allergic diseases.
The surface of the prepared ultra-small cerium oxide nanoenzyme is rich in oxygen holes.
In order to maintain the charge balance, Ce3+ and Ce4+ exist around the oxygen holes.
Among them, Ce4+ can be combined with the phosphorus-oxygen bond of the phosphorylated substrate, and Ce3+ can be combined with water molecules to efficiently catalyze the hydrolysis and dephosphorylation of the phosphorylated substrate, and the hydrolyzed product can be desorbed from its surface to regenerate the active site.
Using this characteristic of ceria nanozyme, the nano stabilizer can continuously regulate the degranulation-related phosphate signal cascade in the allergen-stimulated mast cells to inhibit the release of inflammatory mediators, thereby inhibiting the occurrence of pathological reactions related to allergic mediators , And finally achieve long-term prevention of allergic diseases.
This research provides a new strategy for long-term prevention of allergic diseases.
Related papers are published in Advanced Science (DOI: 10.
1002/advs.
202004115).
The first authors of the article are PhD student Lin Peihua from Zhejiang University and PhD student Cao Mengda from Nanjing Medical University.
The corresponding authors are Fangyuan Li of Zhejiang University, Jifu Wei of Nanjing Medical University and Shanghai Jiaotong University Professor Ling Daishun.
Original link: https://onlinelibrary.
wiley.
com/doi/10.
1002/advs.
202004115
Long-term prevention of allergic diseases.
Key words cerium oxide nanoenzyme, phosphatase-like activity, mast cells, treatment time window, allergic disease prevention More than 25% of people worldwide suffer from a variety of allergic diseases, including asthma, rhinitis, food allergies, etc.
However, about 90% of patients are not well treated, which brings unbearable pain and economic burden to patients.
Allergic disease is a pathological immune response that involves a series of immune cells.
Among them, mast cells are the main effector cells.
When stimulated by an allergen, mast cells will activate the phosphate signal cascade in the cell to cause a series of "domino effects", including the production of reactive oxygen species (ROS), degranulation, release of allergic mediators, and pathological reactions, which can cause allergies.
The occurrence of sexual diseases.
Currently, antihistamines, steroids and non-steroidal anti-inflammatory drugs are commonly used clinically to treat allergic diseases.
However, these drugs can only relieve pathological symptoms and cannot prevent the occurrence of allergic diseases.
Mast cell stabilizers can inhibit the degranulation of mast cells and release inflammatory mediators, which is expected to prevent the occurrence of allergic diseases.
However, most small molecule mast cell stabilizers (including the gold standard cromolyn disodium) have a narrow treatment time window, and patients with allergic constitution often miss the optimal administration time of mast cell stabilizers.
Therefore, the development of mast cell stabilizers with a long therapeutic time window is essential for the prevention of allergic diseases.
Professor Li Fangyuan of Zhejiang University, Professor Wei Jifu of Nanjing Medical University, and Professor Ling Daishun of Shanghai Jiaotong University prepared a cerium oxide nanozyme with phosphatase-like activity in response to this problem and designed it as a mast cell nano stabilizer for use Long-term prevention of allergic diseases.
The surface of the prepared ultra-small cerium oxide nanoenzyme is rich in oxygen holes.
In order to maintain the charge balance, Ce3+ and Ce4+ exist around the oxygen holes.
Among them, Ce4+ can be combined with the phosphorus-oxygen bond of the phosphorylated substrate, and Ce3+ can be combined with water molecules to efficiently catalyze the hydrolysis and dephosphorylation of the phosphorylated substrate, and the hydrolyzed product can be desorbed from its surface to regenerate the active site.
Using this characteristic of ceria nanozyme, the nano stabilizer can continuously regulate the degranulation-related phosphate signal cascade in the allergen-stimulated mast cells to inhibit the release of inflammatory mediators, thereby inhibiting the occurrence of pathological reactions related to allergic mediators , And finally achieve long-term prevention of allergic diseases.
This research provides a new strategy for long-term prevention of allergic diseases.
Related papers are published in Advanced Science (DOI: 10.
1002/advs.
202004115).
The first authors of the article are PhD student Lin Peihua from Zhejiang University and PhD student Cao Mengda from Nanjing Medical University.
The corresponding authors are Fangyuan Li of Zhejiang University, Jifu Wei of Nanjing Medical University and Shanghai Jiaotong University Professor Ling Daishun.
Original link: https://onlinelibrary.
wiley.
com/doi/10.
1002/advs.
202004115
