Biol Trace Elem Res: People with polycystic ovary syndrome have higher levels of oxidative stress than normal.

This study assessed serum copper and magnesium and total antioxidant capacity levels in PCOS patients.
, the possible association between copper and magnesium and total antioxidant capacity (TAC) was studied.
150 women (60 PCOS patients and 90 healthy subjects) participated in the case-control study.
is diagnosed as PCOS according to rotterdam standards (2003).
the serum Cu, Mg, Ca, TAC, insulin levels and insulin resistance indices.
elisa method was used to determine insulin levels.
the serum Cu and Mg levels using atomic absorption photometers and Xylidyl Blue, respectively.
analysis of the correlation between the parameters using Thespearman-related tests.
results showed that the serum Cu level was significantly higher in PCOS patients than in the control group, while the TAC was significantly lower than in the control group (P.019 and P.002, respectively).
no significant differences were found between the two groups in terms of serum Mg and Ca levels and Ca/Mg ratios.
In PCOS subjects with insulin resistance, there was a negative correlation between the Mg level and the steady-state model evaluation of insulin resistance (r - 0.449, p - 0.006), but there was a positive correlation between the Mg level and the quantitative insulin sensitivity test index (r s 0.480, p s 0.003).
in PCOS patients with non-insulin resistance, there was also a negative correlation between Mg levels and TAC (r - 0.407, p - 0.04).
results, copper and magnesium appear to help oxidative stress and insulin resistance in PCOS patients.
therefore, in order to prevent long-term metabolic complications in PCOS women, it is recommended that these elements be routinely monitored.
, serum TAC levels in PCOS patients were significantly lower than in normal women, which may indicate elevated oxidative stress levels in such patients.
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