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Iron homeostasis is maintained by the physiological negative feedback regulation of 25 amino acid peptides produced by liver cells
.
In patients with medium or severe β-thalassemia, hepcidin is significantly inhibited by the overexpression of growth differentiation factor 15 (GDF15).
In patients with medium or severe β-thalassemia, hepcidin is significantly inhibited by the overexpression of growth differentiation factor 15 (GDF15).
Due to maternal blood expansion, placenta and fetal growth leading to increased iron requirements, iron deficiency and even iron deficiency anemia (IDA) may occur
In fact, in pregnant women with β-thalassemia, whether GDF15 inhibits hepcidin has not been studied
.
In addition, there is no report on whether the iron metabolism characteristics and iron supplementation effects of such pregnant women are consistent with those with IDA alone
In fact, in pregnant women with β-thalassemia, whether GDF15 inhibits hepcidin has not been studied
A foreign research team compared and analyzed four groups of blood routine parameters, iron metabolism parameters, GDF15 levels and heparin levels, namely-thalassemia (β) + IDA, β group, IDA group and normal group
These results indicate that in pregnant women with mild β-thalassemia, hepcidin functions normally to maintain iron homeostasis, and iron supplementation is effective and safe
Original source:
Chen, N.
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