Blood: A high-order link between stereotyped subsypes of chronic lymphocytic leukemia.

Chronic lymphocytic leukemia (CLL) is characterized by the presence of the same, stereotyped B-cell-like immunoglobulin (BcR IG) sub-group.
patients in certain major sub-groups tend to exhibit very consistent clinical biology characteristics, suggesting that CLL's BCR IG stereotyped research is important for understanding pathophysiology of diseases and improving clinical decision-making.
, however, several issues remain unresolved, particularly with regard to the actual frequency of BCR IG stereotypes and major subsypes, as well as the higher-order links between subsypes.
to solve these problems, Andreas et al. studied the clone IGHV-IGHD-IGHJ gene rearring in 29,856 CLL patients, the largest queue in the world to date. the
-stereotyped CLL's IGCV gene spectrum is significantly different from the general queue results show that the peak of the stereotyped portion of the CLL accounts for 41% of the entire queue, all 19 major subtypes previously identified maintain their relative proportions and rankings, and 10 new subtypes have emerged;
The main stereotyped subsype represents a significantly higher level of relationship between the main subsypes of the CLL, especially the main stereotyped subsype with the un mutated IGCV gene (U-CLL), which is closely related to other subsypes known as "satellites".
satellite subset accounts for 3 per cent of the entire queue.
The clinical characteristics of the rigid subtype and its satellite subsets are consistent, and these results confirm the previous view of Andreas and others that the main subtypes can be well identified and consistent in relative proportion, and therefore represent different disease variants, suitable for zoning studies, and have the potential to overcome the obvious heterogeneity of CLL.
addition, the existence of satellite subsets reveals a new aspect of genealogy limitation, which is of great significance to the fine molecular classification of CLL.
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