Blood: A new red blood cell production regulation mode

Eryteonin (Epo) provides the primary survival signal for mature erythropoietin (EPs) and is essential for end-of-life erythropoietin productionStill, progenitor cells can irreversibly differentiate into the red line before Epo plays, but if these progenitor cells are not needed to maintain the red blood cell (RBC) count, they will be wastedrecently, researchers have identified a new type of red blood cell-generated patterned tissue, and for the first time demonstrated that the pre-Epo model is coupled with late Epo-dependent red blood cell production through macronuclear cell signalsTgfb1, which destroys macronuclear cells, can cause hematopotic dysfunction by expanding the epo pre-pool of progenitor cells, and thus trigger a significant apoptosis of the Epo-dependent red line precursorsimilar, pharmacological blocking of TGF beta signals in normal mice enhances the pre-Epo pattern, leading to Epo-sensitive EP apoptosisSubsequent treatments with low doses of Epo triggered a large production of RBC in both models, this study reveals the patterned regulation of red blood cell generation and provides a new strategy for overcoming chronic anemia