Blood: Antibodies that inhibit platelet phagocytosis, or treat ITP
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Last Update: 2020-06-24
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Source: Internet
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Author: User
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Multi-clone anti-D is a first-line therapy for immune platelet reduction (ITP)Monoclonal antibodies are ideal alternatives, but although they have the ability to regulate red blood cells and cause anemia, none has been proven successfulIn this study, researchers examined 12 different specific and subtype mouse red blood cell-specific antibodies and found that eight of them induced anaemia in antigen-positive miceOf these eight antibodies, only five improve ITPThe researchers tested the ability of all antibodies to support macrophages mediated by red blood cells in vitroAntibodies that support red blood cell phagocytosis in vitro have successfully improved ITP in the bodyTo test each antibody's ability to inhibit platelet swallowing, the researchers used the antibody in vitro to sensitize red blood cells and added them to platelet phage experimentsAntibodies that inhibit platelet phony in vitro can also improve ITP in the bodyit is known that inducing anemia is not a sufficient condition for improving ITP, in vitro antiplatelet swallowing ability can predict its ability to improve ITPThis study suggests that in vitro platelet-eatingolet suppression experiments may be a valuable tool to screen which red blood cell antibodies can be applied to ITP clinical treatment
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