Blood: Changes in the diversity of intestinal virlobis in patients during the transplantation of in-body stem cells and their correlation with the prognosis of transplantation

Previous studies have suggested a decrease in fecal micro-biodiversity in patients with allo-HCT.
similar antibiotic exposure and nutritional changes occur in patients who receive high doses of chemotherapy and auto-HCT.
To study the fecal microbiome characteristics of patients with auto-HCT, Khan and others analyzed 1,161 stool samples from 534 adult subjects of auto-HCT in an observational study conducted at two transplant centers in the United States on lymphoma, myeloma, and amyloid degeneration.
sequencing 16S icing glycosome genes, the researchers used an anti-Simpson index to assess the diversity and composition of the fecal microbiome.
micro-biodiversity of fecals in patients with two centers of fecal micro-biodiversity and prognosis during transplantation in patients with auto-HCT was lower than that of the healthy control group long before transplantation and was further reduced during transplantation.
in the auto-HCT process, the pattern of loss of fecal microbiobiota and the dominant position of specific bacteria in transplant recipients is similar to that in the allo-HCT process.
during transplantation, fecal intestinal diversity above the medium level was associated with a reduced risk of death or progress (PFS HR 0.46 (95% CI, 0.26-0.82) and P=0.008).
the characteristics of intestinal bacteria during auto-HCT, the study suggests that during auto-HCT, the intestinal microbiota diversity of transplanted patients is destroyed, and the more severely the intestinal bacterial diversity is impaired, the worse the patient's prognosis.
the health of the intestinal bacteria and the prognosis of transplantation in patients with self-transplantation should be further studied.