Blood: Chromosome 20 loss is a feature of degenerative large cell lymphoma associated with breast implants.

Breast implant-related degenerative large cell lymphoma (BIA-ALCL) is a very rare type of T-cell lymphoma caused by a single environmental stimulus.
In this study, Tjitske and others performed a comprehensive genetic analysis of a relatively large BIA-ALCL queue (n=29), including genome-wide chromosomal copy number variation (CNA) and mutations in a subset (n=7).
24 cases of ALC-negative CNA in the knot were selected for comparison.
(29 cases of BIA-ALCL CNA) detected CNA in 94% of BIA-ALCL samples, and 66% of BIA-ALCL samples carried chromosome 20q13.13 missing.
20q13.13 is a characteristic of BIA-ALCL that distinguishes it from other types of ALCL (e.g. primary skin-type ALCL, systemic APK-positive, and negative ALCL).
mutation mode confirms that the IL6-JAK1-STAT3 signal path is deregated.
although this is commonly observed in different types of T-cell lymphoma, the IL6-JAK1-STAT3 signaling path path of BIA-ALCL is significantly more regulated, as shown by pSTAT3 immunologic chemistry.
(A: CNA statistics in patients with serotylus-BIA-ALCL; B: serum swelling-BIA-ALCL and tumor-BIA-ALCL heterogeneity) Chromosome 20 characteristic loss in BIA-ALCL further proves that BIA-ALCL is an independent disease entity.
addition, CNA analysis can be used as a parameter for future diagnostic tests for women with breast implants to distinguish between serum swelling caused by BIA-ALCL and other causes of serotonia aggregation, such as infection or trauma.
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