Blood: High plasma GDF-15 levels are associated with an increased risk of venous thrombosis.

Central point: High GDF-15 levels are strongly associated with an increased risk of venous thrombosis, and Mendel randomized analysis shows that GDF-15 is a risk marker of venous thrombosis, not a risk factor for disease.
: Growth differentiation factor 15 (GDF-15) is a marker of inflammation and oxidative stress and has become a biomarker of arterial cardiovascular disease.
, however, the relationship between GDF-15 and venous thrombosis (VTE) remains uncertain.
, Hansen and others investigated the relationship between plasma GDF-15 levels and the risk of future venous thrombosis, and used mendel randomization (MR) methods to explore the possibility of causation.
this was a population-based nested case-control study that recruited 416 patients with venous thrombosis and 848 age- and gender-matched controls from the Troms?study.
Logistic regression is used to calculate the advantage ratio (OR) of venous thrombosis between GDF-15 quarterconates.
results, the OR value of VTE increases in the GDF-15 quarter digits (trend P.002).
in the age and gender-adjusted model, subjects with GDF15 values in the highest quarter digits (-358pg/mL) had 2.05 (95% CI 1.37 to 3.08) vs. subjects with GDF15 values in the lowest quarter digits (?lt;200pg/mL).
after further correcting body mass index, smoking, hormone therapy, physical activity, and C-reactive proteins, ORS remained essentially the same.
similar results in induced/non-induced events, deep vein thrombosis, and pulmonary embolism.
consistent with SNPs forecasts, in MR, the GDF-15 level is independent of VTE.
results of this study show that high GDF-15 levels are associated with increased risk of VTE, but Mendel's random analysis suggests that this link is not causal.
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