Blood: MDH1 mediated malic acid-tinline NADH cycle maintains fetal liver HSC activity

The relationship between the energy metabolism and dryness of hematopoietic stem cells (HSCs) at different stages of development is largely unclearIn this study, Hao and others established a genetically modified mouse line age with a genetically coded NADH/NAD-plus sensor (SoNar) and demonstrated the presence of three different fetal liver hematopoietic cell groups based on SoNar fluorescence ratiosMitochondrial breathing levels were increased in low-lying cells of SoNar, but glycoenzyme levels were similar to those of cells with high SoNarInterestingly, 10% of low SoNar cells contain 65% of immune phenopharycin hematopoietic stem cells (FL-HSCs) and contain about five times as many functional HSCs as high SoNar cellsSoNar can sensitively monitor changes in the dynamics of energy metabolism of HSCs in and out of the bodyin mechanism, STAT3 transactivation MDH1 to maintain the malic acid-tinline NADH shuttle activity and HSC self-renewal and differentiation, this study reveals the metabolic processes of FL-HSCs and provides a powerful genetic tool for the metabolic study of HSCs or other types of stem cells