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    Home > Active Ingredient News > Blood System > BLOOD: Targeted membrane-bound anionic phospholipid anticoagulation therapy can improve the outcome of traumatic brain injury in mice

    BLOOD: Targeted membrane-bound anionic phospholipid anticoagulation therapy can improve the outcome of traumatic brain injury in mice

    • Last Update: 2021-10-19
    • Source: Internet
    • Author: User
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    Severe traumatic brain injury (TBI) usually leads to an acute systemic hypercoagulable state and rapidly develops into wasting coagulopathy


    Severe traumatic brain injury (TBI) usually leads to an acute systemic hypercoagulable state and rapidly develops into wasting coagulopathy


    Foreign team recently demonstrated that a severe traumatic brain injury TBI-induced coagulopathy (TBI-IC) initiated and propagated by the outer vesicle brain-derived cells (BDEV), the outer cell vesicles by endothelial cells and platelets (EV ) Spread


    They evaluated the effect of the fusion protein (ANV-6L15) on improving the results of TBI


    They evaluated the effect of the fusion protein (ANV-6L15) on improving the results of TBI


    They made two key points:
    • 1) A fusion protein with an anticoagulant peptide linked to Annexin V binds to circulating extracellular vesicles


    • 2) This fusion protein can prevent wasting coagulopathy and improve the prognosis of mice suffering from severe traumatic brain injury


  • 1) A fusion protein with an anticoagulant peptide linked to Annexin V binds to circulating extracellular vesicles


  • 1) A fusion protein with an anticoagulant peptide linked to Annexin V binds to circulating extracellular vesicles


  • 2) This fusion protein can prevent wasting coagulopathy and improve the prognosis of mice suffering from severe traumatic brain injury


  • 2) This fusion protein can prevent wasting coagulopathy and improve the prognosis of mice suffering from severe traumatic brain injury


    prevention

    These findings indicate that TBI-IC is caused by a hypercoagulable state caused by trauma and can be used for anticoagulation treatment by targeting the anionic phospholipid expressing membrane of EVs from the brain and other cells


    These findings indicate that TBI-IC is caused by a hypercoagulable state caused by trauma and can be used for anticoagulation treatment by targeting the anionic phospholipid expressing membrane of EVs from the brain and other cells


    Original source:

    Xinlong Dong, Wei Liu, Yu Shen, Katie L Houck, Mengchen Yang, Yuan Zhou, Zilong Zhao, Xiaoping Wu, Teri Blevins, Amanda L.


    Xinlong Dong, Wei Liu, Yu Shen, Katie L Houck, Mengchen Yang, Yuan Zhou, Zilong Zhao, Xiaoping Wu, Teri Blevins, Amanda L.


     



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