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Severe traumatic brain injury (TBI) usually leads to an acute systemic hypercoagulable state and rapidly develops into wasting coagulopathy
Severe traumatic brain injury (TBI) usually leads to an acute systemic hypercoagulable state and rapidly develops into wasting coagulopathy
Foreign team recently demonstrated that a severe traumatic brain injury TBI-induced coagulopathy (TBI-IC) initiated and propagated by the outer vesicle brain-derived cells (BDEV), the outer cell vesicles by endothelial cells and platelets (EV ) Spread
They evaluated the effect of the fusion protein (ANV-6L15) on improving the results of TBI
They evaluated the effect of the fusion protein (ANV-6L15) on improving the results of TBI
They made two key points:
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1) A fusion protein with an anticoagulant peptide linked to Annexin V binds to circulating extracellular vesicles
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2) This fusion protein can prevent wasting coagulopathy and improve the prognosis of mice suffering from severe traumatic brain injury
1) A fusion protein with an anticoagulant peptide linked to Annexin V binds to circulating extracellular vesicles
1) A fusion protein with an anticoagulant peptide linked to Annexin V binds to circulating extracellular vesicles
2) This fusion protein can prevent wasting coagulopathy and improve the prognosis of mice suffering from severe traumatic brain injury
2) This fusion protein can prevent wasting coagulopathy and improve the prognosis of mice suffering from severe traumatic brain injury
prevention
These findings indicate that TBI-IC is caused by a hypercoagulable state caused by trauma and can be used for anticoagulation treatment by targeting the anionic phospholipid expressing membrane of EVs from the brain and other cells
These findings indicate that TBI-IC is caused by a hypercoagulable state caused by trauma and can be used for anticoagulation treatment by targeting the anionic phospholipid expressing membrane of EVs from the brain and other cells
Original source:
Xinlong Dong, Wei Liu, Yu Shen, Katie L Houck, Mengchen Yang, Yuan Zhou, Zilong Zhao, Xiaoping Wu, Teri Blevins, Amanda L.
Xinlong Dong, Wei Liu, Yu Shen, Katie L Houck, Mengchen Yang, Yuan Zhou, Zilong Zhao, Xiaoping Wu, Teri Blevins, Amanda L.
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