Blood: The incidence of thrombosis in children and adolescents with new coronary pneumonia or MIS-C

Central point | Cancer, central venous catheters, older age and MIS-C are all risk factors for thrombosis in children and adolescents with new coronary pneumonia or MIS-C ; mortality in children and adolescents with MIS-C or new coronary pneumonia with thrombosis Very high (28%) .

Central point | Cancer, central venous catheters, older age and MIS-C are all risk factors for thrombosis in children and adolescents with new coronary pneumonia or MIS-C ; mortality in children and adolescents with MIS-C or new coronary pneumonia with thrombosis Very high (28%) .

The center point of the new crown pneumonia Children thrombosis

The new coronary pneumonia ( COVID-19 ) caused by the new coronary pneumonia virus (SARS-CoV-2) is related to adult thrombosis complications, but the incidence of new coronary pneumonia-related thrombosis in children and adolescents is unclear
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COVID-19

Most children with acute new coronary pneumonia are mildly ill, but coagulation dysfunction is associated with multiple system inflammatory syndrome (MIS-C, a post - infection complication) in children
.

Multiple system inflammatory syndrome (MIS-C, a post - infection complication) infection

Researchers such as Whitworth conducted a multi-center retrospective cohort study to determine the incidence of thrombosis in hospitalized children with new coronary pneumonia or MIS-C, and to assess related risk factors
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Researchers divided the children into 3 groups for analysis: the new coronary pneumonia group, the MIS-C group or the asymptomatic infection group
.

Receiving dosage strength divided by clinical subgroups preventing patients proportionality anticoagulation

Divided by the dose strength clinical subgroups receiving prevention proportion of patients anticoagulation prophylaxis

A total of 814 patients were enrolled and a total of 853 hospitalizations (426 cases of new coronary pneumonia, 138 cases of MIS-C, and 289 cases of asymptomatic infection), of which 20 children had thrombotic events (TE; including one stroke )
.
Compared with new coronary pneumonia or asymptomatic infection, children with MIS-C have the highest thrombosis rate (MIS-C vs COVID-19 vs asymptomatic infection: 6.
5% [9 cases] vs 2.

1% [9 cases] vs 0.
7% [2 cases ])

Compared with new coronary pneumonia or asymptomatic infection, stroke children with MIS-C have the highest thrombosis rate (MIS-C vs.

Preventive anticoagulation program for children with new coronary pneumonia or MIS-C

Preventive anticoagulation program for children with new coronary pneumonia or MIS-C

Among children with new coronary pneumonia or MIS-C, most TE (89%) occurred in children ≥12 years of age
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Children with MIS-C ≥12 years of age have the highest thrombosis rate, as high as 19% (9/48)

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Among children with new coronary pneumonia or MIS-C, most TE (89%) occurred in children ≥12 years of age

Factors that are significantly related to thrombosis are: children with ≥12 years of age, cancer, central venous catheters, and MIS-C new coronary pneumonia or MIS-C.

Original source:

Original source:

Hilary Whitworth, et al.

Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C in this message