Blood: The mechanism by which malaria parasites develop in human red blood cells and affect host red blood cell generation

BACKGROUND: The malaria parasite has two hosts, mosquitoes and humans, in the human body has been parasitic in liver cells and red blood cells, cracking proliferation (schizogony)In red blood cells, in addition to the proliferation of cleavage, the division of the gene forms a ligand and begins the initial development of sexual reproductionIn the mosquito body, the matching sub-reproduction (gametogony) is completed, followed by spore proliferation (sporogony)Plasmodium falciparum ligand cells are the most sexual stages that cause the spread of the malaria parasite from humans to mosquitoes and are the main targets for the elimination of malariaImmature matching cells develop in the actual tissues of human bone marrow and gather around red blood cell-producing islandshowever, it is worth noting that the interaction between the matching cells and the hematopoietic niche has not been studiedrecently published an article in the journal Blood, Gaelnev et alfound that late red blood cells are new host cells in the plasmodium progenitor stage, and that matching subsomecs can fully develop in these nuclear cells (whether in vivo or in vitro), leading toinfections in mesh red blood cellsmature sidenssurprisingly, an extracellular vesicle infection derived from the ligand cells and parasites can delay red line differentiation, allowing the matchto to mature and its host cells to release from the bone marrow at the same timein general, the study highlights a new mechanism for the development of immature malaria parasite matchmakers in the bone marrow, providing further insight into how the malaria parasite affects red blood cell production and causes anemia in patients