Blood: The mother ferritin, not the fetal iron tone, determines the fetal iron steady state!

Iron disorders are associated with poor pregnancy outcomes, but we still know little about the mechanisms that maintain iron stability during pregnancyIn humans and rodents, the iron-regulating hormone ferritin is greatly reduced in pregnant mothers, which is thought to ensure that there is enough iron for placental metastasisBut the fetal liver also produces ferritin, which may regulate the metabolism of the fetus by controlling the export of placental ironTo determine the relative contribution of maternal and embryonic ferrite to regulating the iron metabolism of embryos when iron is sufficient or iron overloaded, the researchers established a mouse model of the mother or embryo lack ingeninfound that it was the mother's ferritin, not the fetal iron totone, which determines the iron metabolism of the embryo and placenta during a healthy pregnancyThe researchers further found that inflammation can counteract the inhibition of maternal ferrite dependence on pregnancyIn order to analyze the necessary inhibitory effect of maternal ferritin on the stable iron state of the embryo, the researchers simulated the range of maternal ferrite-torin activity by similarity of ferrite peptides in pregnant miceThe method could also help researchers determine the effects of excessive maternal ferritin alone on pregnancy, with no mixed effects of inflammationfound that high doses of ferrite preparations can lead to maternal iron restriction and anemia, placental and fetal weight loss, fetal anemia, and increased fetal mortalityLow doses of ferritin preparations do not cause maternal anemia, but still have adverse effects on the fetus, leading to anemia, iron deficiency in tissues (including the brain) and weight loss, this study proves that maternal iron tone inhibition during pregnancy is very important for both maternal and fetal iron steady state and health