Blood: The neurotransmitter subject GABBBR1 directly regulates the proliferation and function of hematologic stem/progeny cells.

The hematologic system and nervous system are linked by the nerve domination of the bone marrow (BM) niche cells.
hematopoietic dry/progenitor cells (HSPCs) express neurotransmitter subjects, such as g-amino butyric acid (GABA) type B-type ligand sub-base 1 (GABBR1), suggesting that HSPCs can be regulated directly by neurotransmitters such as GABA in combination with GABBR1.
Shao et al., using imaging mass spectrometrometography (IMS), found that endogenous GABA molecules were collected in the area around the endosome in the BM niche.
to better understand GABPR1's ability to regulate HSPCs, Shao et al. built a mouse model of the compositional Gabbr1 knock-off.
analysis found that Gabbr1 knocked out a significant reduction in the number of HSPC in mice compared to wild mice.
, Gabbr1-/-hematopoietic stem cells (HSCs) were less likely to reconstruct radiation-treated mice in competitive transplant models.
(Gabbr1-/- Hematopoietic Stem Cell Proliferation weakens, accompanied by B-cell line amplification) The proliferation of Gabbr1-/- Hematopoietic Stem Cells decreases in both stable and stressed conditions.
cloning experiments show that almost all Gabbr1-/-HSPC is in a slow or non-circular state.
in-body co-culture, Gabbr1-/-HSPC produced a small number of cells, accompanied by significant differentiation defects and B-cell line amplification.
In order to determine whether GABBR1 agonists stimulate human cord blood (UCB) HSPC, the researchers conducted a brief in-body treatment prior to transplanting UCB HSPC to immunodeficiency mice, and the results showed a significant increase in the long-term transplantation of HSPC treated with GABBR1 agonists compared to GABBR1 antagonists or blank therapy.
, the results of this study show that GABBR1's direct role in HSPC proliferation may be a potential target for improving the prognostication of HSPC transplantation in clinical transplantation.
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