Blood: THE OCCURRENCE OF MYC INDUCED AML REQUIRES CONTINUOUS CO-STIMULATION OF IL3 AND GM-CSF

In healthy people, hematopoietic cloning with a sudden leukemia occurs with age, but rarely progresses into acute myeloid leukemia (AML)Recent evidence suggests that microenvironments may play an important role in human AML dynamicsin order to study this possibility, Elizabeth Bulaeva et altested the combined and individual effects of cancer genes (c-MYC) and IL-3, GM-CSF, and SCF exposure to xenotransplant
immunodeficiency mice in experimental human AMLpreliminary experiments showed that the normal human CD34 plus blood cells that transfected the MEC to immune-deficiency mice, these cells will quickly develop lethal amplification, phenotype and transcription spectrum are similar to human AML cells, but only in genetically modified mice that produce IL3, GM-CSF and SCF, or in mice that use co-dye-transmission strategies to expose cells to IL3 or GM-CSFin the absence of IL3, GM-CSF, or SCF, MYC-human cells can produce normal lymphatic and myelin cells for several months in transplanted mice, but when transferred to mice that produce human cytokines, MYC-cells quickly produce AMLthese findings underscore the key role of these cytokines (IL3, GM-CSF, and SCF) in activating the malignant state of normally differentiated artificial blood cells