Blood: The regulatory mechanism for protein reconstruction and cell removal in the final stage of red blood cell production.

The final stages of mammalian red blood cell production include denuclearization, membrane and proteomic remodeling, and cellular removal.
, the red blood cell membrane skeleton establishes a unique hexagonal spectral network that connects the complex to the membrane.
, the mechanisms and signaling paths involved in coordinating these processes are unclear.
study, researchers revealed an unexpected role in proteomic remodeling and cellular removal in the final stages of red blood cell production.
, Liu and others have found that forin mDia2, which is related to transparent proteins, is the main regulator of membrane skeleton integrity and works primarily by polymerization of the pathogens in the complex.
the end-of-life red line cells with MDia2 defects contain a loose and stiff membrane skeleton that cannot effectively isolate the excreted nuclei.
addition, the fractured membrane skeleton does not activate the ESCRT-III complex, causing proteomic remodeling, endosomal transport, and autophagy to remove overall barriers.
researchers also found that, as part of the ESCRT-III complex, Chmp5 is regulated by the activation of serum reaction factors dependent on mDia2, which is necessary for membrane remodeling and autophagy-lysosome fusion.
missing hematocyte Chmp5 in the body were similar to the esoteric patterns of mice removed by the mDia2 gene.
, over-expression of Chmp5 in the hematostomatic dry/ancestral cells of mDia2 defects can significantly restore end-of-life red blood cell production in the body.
together, these findings reveal a signaling path that is regulated by the formin during the eventual red blood cell generation process, linking the membrane skeleton to proteomic reconstruction, denuclearization, and cellular removal.
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