Blood: The severity of the graft's resistance to host disease can be regulated by a type 2 cannabinin recipient.

The immune system includes congenital and adaptive immunity (access to immunity).
-host disease (GVHD) is a tug-of-war between adaptive and congenital immunity.
, the effectiveness of prevention strategies depends on the reasonable treatment of the intensity of adaptive and congenital immunity.
In this study, Cheng Yin Yuan and others studied the effects of type 2 cannabinin-infested (CB2R) expressed on almost all immune cells, demonstrating the lack of CB2R on the cells of the ligand CD4 plus or CD8 plus T, or giving selective CB2R pharmacological antagonists to increase the fatality rate of acute GVHD.
this is also accompanied by the significant expansion of inflammatory CD8-T cells, suggesting that CB2R's compositional expression on T-cells prioritizes the regulation of allogeneic regeneration of CD8-T cells.
reported in mice through a new CB2R-EGFP, the researchers observed a significant decrease in expression of CB2R on T cells during acute GVHD, but not on macrophages, indicating different changes in the expression of the subjects of different cells under inflammatory conditions.
treatment of THC and JWH-133 on the severity of chronic GVHD with the treatment of the astigids tyhydrocannabinol (THC) and JWH-133 targeted CB2R showed that only THC could reduce the acute GVHD of fatal T-cell mediatation.
, only JWH-133 was effective in the chronic GVHD model of sclere disease (the occurrence of macrophage-mediated lesions).
in-body, both THC and JWH-133 can be collected and ERK phosphorylation through CB2R-induced inhibitor protein (arrestin), but THC does not affect CB2R-mediated adenosine cyclase inhibition.
above, these studies show that CB2R plays a key role in the regulation of GVHD and suggest that effective targeted treatment depends on the signal characteristics of the astration and the selectivity of the subject, as well as the composition of pathogenic immune effect cells.
.