Blood: Transcription Factor ETS1 Regulates NK Cell Development and End-End Differentiation
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Last Update: 2020-06-24
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Source: Internet
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Author: User
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Center point:people's LACK of ETS1 inhibits the expression of several NK cell-related key transcription factors and NK cell differentiationETS1 is essential for tumor cell induced NK cytotoxicity and ifN-gamma productionSummary:natural killer cells (NKs) play an important role in the immune defense of tumor cells and pathogens, and regulate other immune cells through the secretion of cytokinesAlthough the biology of NK cells in mice has been widely studied, knowledge of transcription pathways regulating the development and maturation of human NK cells is limitedby expressing dominant negative ETS1 p27 subtypes in human embryonic stem cells (hESC) that produce ETS1 defects and in umbilical blood (CB) hematopoietic progenitor cells (HPCs), the researchers found that transcription factor ETS1 is a key factor in human NK cell differentiationThe genome transcription group analysis of RNA sequencing combined with chromatin immunoprecipitation (ChIP-seq) showed that human ETS1 can directly induce the expression of the key transcription factors E4BP4, TXNIP, TBET, GATA3, HOBIT and BLIMP1 to control NK cell differentiation, ETS1 regulates the expression of genes associated with apoptosis and NK cell activationthis study reveals the molecular mechanism of ETS1 as an important regulatory factor for human NK cell development and end-to-end differentiation
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