Blood: UTX maintains hemastation by regulating gene expression associated with aging

The maintenance of the hemastogenesic system is essential to the maintenance of the metastrogeneic system, and the control of the presumed genetic system can lead to disorders of the hemaganic system if it gets out of control.
UTX (ubiquitously transcribed tetratricopeptide repeat, chromosome X), also known as KDM6A, is the demethylase of lysine 27 on histoprotein H3 (H3K27) and is also part of the Compass-like and SWI/SNF complexes.
study, researchers found that UTX played an important role in the hemagic system by globally regulating aging-related genes.
Utx gene defect (Utx-x/ut) mice showed poor bone marrow skewed with stunting, impaired hema production outside myelin, impaired hema production and reconstruction, and increased susceptivity to leukemia, all of which are characteristics of hema production aging.
RNA-sequencing (RNA-seq) analysis of blood cell changes in mice with Utx-utx-sequentia showed that Utx lacked gene expression spectrum for young hematologic dry/progenitocytes (HSPC) to be converted into gene expression spectrometry for older HPCs.
Utx's expression in HSC decreases with age, and in Utx-S/HSPC, the expression of aging-related markers increases, reactive oxygen accumulates, and DNA double-stranded fracture repair is impaired.
Utx-X/Utx-Uty mice's leukemia analysis signaling path and chromatin immunopropetyment (ChIP) analysis combined with RNA-seq data show that UTX promotes hema production stability by maintaining gene expression with age through demethylase dependence and non-dependent odelogene programming.
It is worth noting that there is a significant overlap in the pathf pathf pathologies between Utx/HSPC, aging muscle stem cells, aging fibroblasts, and aging-induced nerve cells, which strongly suggests that there is a common aging mechanism between stem cells in different tissues.
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