Blood: Vascular autonomic nerve function abnormalities in sickle cell disease (SCD)

Subjects of sickle cell disease (SCD) exhibited subjective hypersensitivity to cold and hot sensations in the experimental environment, such as cold exposure and other known causes that causethe potential mechanism of vascularclosureReduced microvascular blood flow (MBF) increases the likelihood that sickle red blood cells will be trapped in the microvascular system, thereby increasing the risk of vascular closureBecause SCD subjects had autonometalytic disorder (dysautonomia), Veluswamy and others speculated that thermal exposure could lead to autonomic neurosensitivity in their microvascular system, which increased the tendency for blood vessels to contract, Veluswamy and others exposed 17 SCDs and 16 control subjects to a set of predetermined threshold temperatures to detect cold and hot and cold/hot pain by placing hot patterns on the right handThe Opposite MBF was measured with a photovolume tracer and the cardiac autonomic nerve balance was assessed with heart rate variabilityfound that after temperature stimulation of detection threshold and pain threshold strength, a significant reduction in MBF on the side hand within a few seconds, in which SCD subjects showed more pronounced vascular constriction (p-0.019)In addition, subjects with chronic obstructive pulmonary disease showed a greater reduction in active blood flow and poor recovery during the interval of heat stimulation (p.042) compared to the control groupThe sCD subjects had a faster rate of vascular contraction than the control group (p-0.033), especially under cold detection stimulation;The enhancement of blood vessel constriction reaction and the reduction of blood flow perfusion due to repeated heat stimulation of SCD are signs of hypersensitivity reaction of microvascular autonomic nervesIn Patients with SCD, the increase dyscosyofe reaction and the decreased blood flow perfusion caused by repeated heat stimulation are symptoms of the hypersensitivity reaction of the autonomic nerve of the microvascular vesselsmicrovascular constriction and decreased blood flow may increase the risk of vascular occlusion associated with SCD vascular occlusion crises, such as cold or stress, irritation of red blood cells