Blood: Very low-risk ALL children with low-intensity induced chemotherapy can get a good prognostic!

Previous data show that about 40% of children with acute lymphoblastic leukemia (ALL) can be cured with limited anti-metabolic chemotherapy.
, however, it is not yet possible to accurately identify children with very low risk (VLR).
present, it is mainly based on the induced treatment of the 19th day of symptoms and minimum residual lesions (MRD) level of the combined performance of 0.01%, to choose low-intensity treatment can achieve good results in patients.
study investigated the effects of early MRD levels of 0.001% to 0.01% on the prognostics of very low-risk ALL patients treated with low-intensity programs.
October 2011-September 2015, a total of 200 patients with good clinical pathological characteristics, induction therapy on the 19th day and the end of the bone marrow flow cytometer test MRD-lt;0.01% of B-cell prescell ALL patients received low-intensity treatment.
the cumulative recurrence rate of event-free survival rate of 5 years was 89.5% (±2.2% standard error sE) and the total survival rate was 95.5% (±1.5% SE).
rate (CIR) was 7% (95% CI 4-11%) over a five-year period.
MRD levels were between 0.001% and 0.01% on the 19th day of induced chemotherapy in 29 patients.
the five-year CIR in these patients was significantly higher than in children with undetected residual lesions (5-year CIR was 17.2% ±7.2% vs 5.3% ±1.7% ;P -0.02).
addition, the study showed that very low-risk ALL children can be cured with low-intensity treatment, suggesting that the very low risk (VLR) classification criteria could be further refined by using more sensitive MRD detection and analysis methods.