BMC Med: Genes that protect kidney function in people with type 2 diabetes of Middle Eastern ancestry

Background: Chronic kidney disease (CKD) is a major public health problem affecting more than 13% of the world's population
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Along with aging, obesity and hypertension, type 2 diabetes (T2D) is one of the leading causes of chronic kidney disease, with 1 in 10 people with diabetes dying from kidney failure

Chronic kidney disease (CKD) is a major public health problem affecting more than 13% of the world's population

Methods: Genome-wide association study (GWAS) analysis of EGFR and 10 other metabolic traits was performed in 1201 Iraqi-born residents of Marmo using linear mixed models to account for family structure
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RESULTS: The strongest association signal was detected in Cst9 (rs13037490; P-value = 2.
4 × 10−13), a gene cluster previously associated with cystatin C-based epidermal growth factor receptors; importantly, here The effector (major) allele is opposite to the effector (minor) allele of the other populations, indicating the existence of favorable selection for this group of genes
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In addition, EGFR (ERBB4), fasting blood glucose (CAMTA1, NDUFA10, TRIO, WWC1, TRAPPC9, SH3GL2, ABCC11), quantitative insulin sensitivity check index (METTL16) and HbA1C (CAMTA1, ME1, PAK1, RORA) were also found.

Figure 1 Relationship between SNPs in Manhattan and A fasting blood glucose, B HbA1C, C EGFR, and D Quicki
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Graphs show −log10P values ​​(y-axis) versus chromosome position (x-axis)

Figure 1 Relationship between SNPs in Manhattan and A fasting blood glucose, B HbA1C, C EGFR, and D Quicki

Figure 2 Map of the region of rs13037490 associated with EGFR on chromosome 20
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-log10-transformed P-values ​​correspond to genomic locations

Figure 2 Map of the region of rs13037490 associated with EGFR on chromosome 20

Table 1 Leading SNPs (with genome-wide significant signals) associated with FG, HbA1C, QuickI and EGFR

Table 1 Leading SNPs (with genome-wide significant signals) associated with FG, HbA1C, QuickI and EGFR

CONCLUSIONS: The genetic effects identified here may help explain why Middle Easterners have better kidney function than Europeans, and the survival advantage of Middle Eastern immigrants with type 2 diabetes is based on a genetic susceptibility to preserved kidney function
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The genetic effects found here may help explain why Middle Easterners have better kidney function than Europeans, and the survival advantage of Middle Eastern immigrants with type 2 diabetes is based on a genetic susceptibility to preserved kidney function
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Original source: Mohamed SA, Fernadez-Tajes J, et al.

GWAS in people of Middle Eastern descent reveals a locus protective of kidney function-a cross-sectional study