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Lipid hypertrophy is a common complication of insulin therapy
.
Despite the prevalence of fat hypertrophy and its potentially dangerous effects on blood sugar regulation, it is still a relatively unresearched problem in diabetes
Lipid hypertrophy is a common complication of insulin therapy
This observational study included 74 type 1 diabetic patients at the Diabetes Center in South East London
.
Participants' insulin-exposed areas were scanned ultrasound with a high-frequency linear probe (6-13 MHz)
This observational study included 74 type 1 diabetic patients at the Diabetes Center in South East London
The average age and duration of diabetes of the participants were 40.
Grading characteristics of fat hypertrophy
Grading characteristics of fat hypertrophy Grading characteristics of fat hypertrophyIn 52 subjects (70%), the thickness of the dermis increased by 30% compared to locally uninjected tissue, while in 36 subjects (48%), the thickness of the dermis increased by 50%
.
The thickness of the abdomen of 22 (40%) subjects and the thigh of 8 (17.
In 52 subjects (70%), the thickness of the dermis increased by 30% compared to locally uninjected tissue, while in 36 subjects (48%), the thickness of the dermis increased by 50%
Conceptual model of fat hypertrophy
Conceptual model of fat hypertrophy Conceptual model of fat hypertrophyThis study shows that insulin-related tissue changes are heterogeneous in nature, including fatty hypertrophy and wider dermal and subcutaneous tissue changes
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The researchers used these observations to establish a conceptual module and also developed an ultrasound grading tool for evaluating tissue changes to guide future research and clinical understanding
This study shows that insulin-related tissue changes are heterogeneous in nature, including fatty hypertrophy and wider dermal and subcutaneous tissue changes
References: Hashem R, Mulnier H, Abu Ghazaleh H, et al Characteristics and morphology of lipohypertrophic lesions in adults with type 1 diabetes with ultrasound screening: an exploratory observational study BMJ Open Diabetes Research and Care 2021;9:e002553.
doi: 10.
1136 /bmjdrc-2021-002553doi: 10.
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