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This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Daisy Guide: Recently, a study published on "Gut" shows that a recommended low-FODMAP diet-limiting fermentable carbohydrates is beneficial to irritable bowel synthesis.
People who respond well to IBS have a large number of specific types of bacteria in their intestines
.
High-FODMAP foods can cause the patient's intestinal wall to stretch and swell, causing abdominal pain, bloating, and changes in bowel habits
.
Before adopting a low-FODMAP diet, two different microbial "features" were discovered, namely "pathogenicity-like" and "healthy-likeness"
.
There are abundant pathogenic microorganisms in harmful Firmicutes
.
After 4 weeks of a low FODMAP diet, the microbiome with pathogenic characteristics became healthier
.
The evidence linking diet, microbiome and pathogenic IBS symptoms is convincing.
If bacteria in pathogenic subtypes are proven to play a pathogenic role in IBS, it may be a new treatment through their metabolic activity.
Provides a target and provides an intermediate marker to evaluate them
.
Research published in the "Gut" magazine shows that people who respond well to the recommended dietary therapy of "restricting fermentable carbohydrate intake" for irritable bowel syndrome (IBS) have a large number of specific types of bacteria in their intestines
.
Researchers published an article entitled "The FODMAP diet: more than just a symptomatic therapy?": gut.
bmj.
com/content/early/2021/10/24/gutjnl-2021-326284 Irritable Bowel Syndrome Irritable bowel syndrome (IBS) is a group of persistent or intermittent intestinal dysfunction diseases characterized by abdominal pain, bloating, bowel habits and/or changes in stool characteristics as clinical manifestations, and lack of gastrointestinal structure and biochemical abnormalities
.
Many people suspect that they have IBS if they have problems with their intestines
.
In fact, IBS officially has a set of diagnostic criteria, called Rome IV criteria, which are used to make an accurate diagnosis of IBS
.
The Roman standard requires a person to experience abdominal pain or discomfort for at least six months, accompanied by obvious changes in bowel habits
.
Researchers say this discovery opens up possibilities for new treatments and better management of this disease that affects 15% of people worldwide
.
The composition of trillions of microorganisms (microbiome) in the gut is believed to play an important role in the development of IBS
.
Limiting fermentable carbohydrates (found in a variety of foods, including wheat, onions, and milk) is usually recommended to relieve symptoms.
This method is called low FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols: Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols).
Sugar, disaccharides, monosaccharides and polyols) diet
.
FODMAP is a collection of short-chain carbohydrates (sugars) that are difficult for the body to absorb.
These carbohydrates cannot be absorbed normally in the intestine, which may aggravate the symptoms of IBS patients
.
FODMAPs are found in many foods and food additives
.
The harm of high FODMAP food to IBS patients is that the excess water and gas brought by FODMAP can cause the intestinal wall to stretch and swell, which leads to common IBS symptoms such as abdominal pain, bloating and changes in bowel habits
.
Low FODMAP foods include: fruits: bananas, strawberries, durians, grapes, grapefruits, melons, kiwis, oranges, passion fruit, papaya, crusty melons, star anise, citrus
.
Note: If it is dried fruit, eat a small amount
.
Vegetables: alfalfa, bamboo shoots, bean sprouts, cabbage, carrots, celery, bergamot, cabbage, green beans, lettuce, olives, potatoes, pumpkins, sweet red peppers, spinach, zucchini (yellow), sweet potatoes, taro, tomatoes, kohlrabi , Sweet potato, green zucchini
.
Seasonings: basil, red pepper, ginger, lemongrass, mint, parsley, rosemary, thyme
.
Cereals: gluten-free bread or other grain foods
.
Rice, oats, polenta, millet, sorghum, quinoa, manioc flour
.
Dairy products: lactose-free milk, oat milk, rice milk, soy milk, hard cheese, soft cheese, lactose-free yogurt
.
Eat less red meat, and perhaps rough, dry, hard foods
.
At the same time, avoid excessive intake of gas-producing foods, such as fresh milk and dairy products, soy products, and soy milk
.
(It is best to try this recipe under the guidance of an experienced dietitian.
Special attention should be paid to the nutritional balance of the food intake to avoid malnutrition
.
) But it is not completely clear how this diet works.
It is unclear whether there are specific genes or molecules that can identify who will do so
.
In order to fill this knowledge gap, the researchers analyzed in detail the stool samples of 56 IBS patients and 56 people living with them, but in the absence of conditions, it is necessary to determine the conversion of food into active molecules in their daily diet The microbial characteristics and genes involved
.
Then, by rechecking their stool samples, they assessed the clinical response of 41 of them after 4 weeks on a low-FODMAP diet
.
Before adopting a low-FODMAP diet, analysis of stool samples from IBS patients revealed two different microbial "features", which researchers call "pathogenic samples" (IBSP) and "healthy sexual samples" (IBSH)
.
Harmful Firmicutes have abundant characteristics of pathogenic microorganisms, including known pathogenic bacteria, such as Clostridium difficile, Clostridium sorghum and Clostridium perfringens, but among the beneficial Bacteroides species, pathogenic bacteria The microbial characteristics are very low
.
Streptococcus parasanguinis (Streptococcus parasanguinis) and S.
timonensis that are commonly found in the oral cavity are also abundant
.
Researchers say that bacterial amino acid and carbohydrate metabolism genes are overexpressed, which may explain the excess of certain metabolites associated with IBS symptoms
.
The healthy microbial characteristics of other IBS patients were similar to those of the control group (family members)
.
After 4 weeks of low FODMAP diet, the microbiome of the control and healthy groups remained unchanged
.
However, the microbiome with pathogenic characteristics has become healthier, with more bacteria and fewer species of Firmicutes
.
Bacterial genes involved in amino acid and carbohydrate metabolism are no longer overexpressed
.
3 out of 4 patients with irritable bowel syndrome improved their symptoms
.
However, IBS patients and patients with pathogenic microbial characteristics have a greater clinical response to a low FODMAP diet than IBS patients and patients with healthy gut microbial characteristics
.
The researchers warned: “The evidence linking diet, microbiome, and pathogenic IBS symptoms is convincing, but after introducing candidate organisms into animal models, research is needed to prove that the relationship between the two is Causality
.
"Nevertheless, they believe their findings may pave the way for the development of microbial characteristics to identify those who respond best to a low FODMAP diet and better manage those who do not respond to a low FODMAP diet
.
They suggested: "If bacteria in the pathogenic subtype are proven to play a pathogenic role in IBS, it may be through their metabolic activity, which provides a target for new therapies and provides an intermediate marker for evaluating them.
Things
.
"The low FODMAP diet plan was first proposed by Monash University
.
In a related editorial, Professor Peter Gibson and Dr.
Emma Halmos of Monash University in Melbourne described the introduction and adoption of the FODMAP diet as a major change in the management of patients with irritable bowel syndrome (IBS) towards integrated care
.
They added that although “this is an effective symptomatic treatment, it brings risks associated with worsening eating disorders, challenging nutritional adequacy, and possibly inducing intestinal flora imbalance
.
” They pointed out some limitations of the study.
, Including improper assessment of FODMAP intake and fiber intake (which also affects the microbiome), but it has not been reported
.
They concluded: Nonetheless, the beauty of this research is not its definite nature, but its ability to create viable innovative hypotheses that can be tested through concentrated research
.
Maybe the FODMAP diet is more than just a symptom treatment
.
Reference materials: https://medicalxpress.
com/news/2021-11-distinct-gut-bacterial-profile-highly.
html Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital
.
Recommendation·Activity [Live] Twist Exome 2.
0, defining a new standard for exome sequencing.
Popular·Article Gut Microbiology [Nature] "What you eat is what you eat"-the evidence is found! Biomarkers that reveal how diet ultimately affects immunity through the gut microbiota [Cell Sub-Journal] Non-coding regions of the cancer genome-the discovery of new prognostic biomarkers Single cell sequencing [Cell] Using single cell sequencing technology to analyze recent 600,000 human cells, Ren Bing’s team draws an ultra-large-scale human genome single-cell chromatin accessibility map! Intestinal microbes [BMC sub-Journal] Open a new door to the treatment of gastrointestinal diseases-the discovery of microbiota Tumor research [Science sub Journal] Dr.
Feng Yang from Baylor College of Medicine and his team discovered that MAPK6 gene can promote cancer growth, and targeting MAPK6 provides an effective treatment strategy for cancer! Diseases and health [Cell News] Long-term large amounts of salt are harmful to health! Vigilance: Research reveals for the first time that a high-salt diet will cause trouble to the brain even if it does not increase blood pressure.
Tumor Research [Nature] Edible oil promotes cancer metastasis, and researchers are actively advancing clinical trials of the first new drug!
Please indicate the source for reprinting.
Author: Daisy Guide: Recently, a study published on "Gut" shows that a recommended low-FODMAP diet-limiting fermentable carbohydrates is beneficial to irritable bowel synthesis.
People who respond well to IBS have a large number of specific types of bacteria in their intestines
.
High-FODMAP foods can cause the patient's intestinal wall to stretch and swell, causing abdominal pain, bloating, and changes in bowel habits
.
Before adopting a low-FODMAP diet, two different microbial "features" were discovered, namely "pathogenicity-like" and "healthy-likeness"
.
There are abundant pathogenic microorganisms in harmful Firmicutes
.
After 4 weeks of a low FODMAP diet, the microbiome with pathogenic characteristics became healthier
.
The evidence linking diet, microbiome and pathogenic IBS symptoms is convincing.
If bacteria in pathogenic subtypes are proven to play a pathogenic role in IBS, it may be a new treatment through their metabolic activity.
Provides a target and provides an intermediate marker to evaluate them
.
Research published in the "Gut" magazine shows that people who respond well to the recommended dietary therapy of "restricting fermentable carbohydrate intake" for irritable bowel syndrome (IBS) have a large number of specific types of bacteria in their intestines
.
Researchers published an article entitled "The FODMAP diet: more than just a symptomatic therapy?": gut.
bmj.
com/content/early/2021/10/24/gutjnl-2021-326284 Irritable Bowel Syndrome Irritable bowel syndrome (IBS) is a group of persistent or intermittent intestinal dysfunction diseases characterized by abdominal pain, bloating, bowel habits and/or changes in stool characteristics as clinical manifestations, and lack of gastrointestinal structure and biochemical abnormalities
.
Many people suspect that they have IBS if they have problems with their intestines
.
In fact, IBS officially has a set of diagnostic criteria, called Rome IV criteria, which are used to make an accurate diagnosis of IBS
.
The Roman standard requires a person to experience abdominal pain or discomfort for at least six months, accompanied by obvious changes in bowel habits
.
Researchers say this discovery opens up possibilities for new treatments and better management of this disease that affects 15% of people worldwide
.
The composition of trillions of microorganisms (microbiome) in the gut is believed to play an important role in the development of IBS
.
Limiting fermentable carbohydrates (found in a variety of foods, including wheat, onions, and milk) is usually recommended to relieve symptoms.
This method is called low FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols: Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols).
Sugar, disaccharides, monosaccharides and polyols) diet
.
FODMAP is a collection of short-chain carbohydrates (sugars) that are difficult for the body to absorb.
These carbohydrates cannot be absorbed normally in the intestine, which may aggravate the symptoms of IBS patients
.
FODMAPs are found in many foods and food additives
.
The harm of high FODMAP food to IBS patients is that the excess water and gas brought by FODMAP can cause the intestinal wall to stretch and swell, which leads to common IBS symptoms such as abdominal pain, bloating and changes in bowel habits
.
Low FODMAP foods include: fruits: bananas, strawberries, durians, grapes, grapefruits, melons, kiwis, oranges, passion fruit, papaya, crusty melons, star anise, citrus
.
Note: If it is dried fruit, eat a small amount
.
Vegetables: alfalfa, bamboo shoots, bean sprouts, cabbage, carrots, celery, bergamot, cabbage, green beans, lettuce, olives, potatoes, pumpkins, sweet red peppers, spinach, zucchini (yellow), sweet potatoes, taro, tomatoes, kohlrabi , Sweet potato, green zucchini
.
Seasonings: basil, red pepper, ginger, lemongrass, mint, parsley, rosemary, thyme
.
Cereals: gluten-free bread or other grain foods
.
Rice, oats, polenta, millet, sorghum, quinoa, manioc flour
.
Dairy products: lactose-free milk, oat milk, rice milk, soy milk, hard cheese, soft cheese, lactose-free yogurt
.
Eat less red meat, and perhaps rough, dry, hard foods
.
At the same time, avoid excessive intake of gas-producing foods, such as fresh milk and dairy products, soy products, and soy milk
.
(It is best to try this recipe under the guidance of an experienced dietitian.
Special attention should be paid to the nutritional balance of the food intake to avoid malnutrition
.
) But it is not completely clear how this diet works.
It is unclear whether there are specific genes or molecules that can identify who will do so
.
In order to fill this knowledge gap, the researchers analyzed in detail the stool samples of 56 IBS patients and 56 people living with them, but in the absence of conditions, it is necessary to determine the conversion of food into active molecules in their daily diet The microbial characteristics and genes involved
.
Then, by rechecking their stool samples, they assessed the clinical response of 41 of them after 4 weeks on a low-FODMAP diet
.
Before adopting a low-FODMAP diet, analysis of stool samples from IBS patients revealed two different microbial "features", which researchers call "pathogenic samples" (IBSP) and "healthy sexual samples" (IBSH)
.
Harmful Firmicutes have abundant characteristics of pathogenic microorganisms, including known pathogenic bacteria, such as Clostridium difficile, Clostridium sorghum and Clostridium perfringens, but among the beneficial Bacteroides species, pathogenic bacteria The microbial characteristics are very low
.
Streptococcus parasanguinis (Streptococcus parasanguinis) and S.
timonensis that are commonly found in the oral cavity are also abundant
.
Researchers say that bacterial amino acid and carbohydrate metabolism genes are overexpressed, which may explain the excess of certain metabolites associated with IBS symptoms
.
The healthy microbial characteristics of other IBS patients were similar to those of the control group (family members)
.
After 4 weeks of low FODMAP diet, the microbiome of the control and healthy groups remained unchanged
.
However, the microbiome with pathogenic characteristics has become healthier, with more bacteria and fewer species of Firmicutes
.
Bacterial genes involved in amino acid and carbohydrate metabolism are no longer overexpressed
.
3 out of 4 patients with irritable bowel syndrome improved their symptoms
.
However, IBS patients and patients with pathogenic microbial characteristics have a greater clinical response to a low FODMAP diet than IBS patients and patients with healthy gut microbial characteristics
.
The researchers warned: “The evidence linking diet, microbiome, and pathogenic IBS symptoms is convincing, but after introducing candidate organisms into animal models, research is needed to prove that the relationship between the two is Causality
.
"Nevertheless, they believe their findings may pave the way for the development of microbial characteristics to identify those who respond best to a low FODMAP diet and better manage those who do not respond to a low FODMAP diet
.
They suggested: "If bacteria in the pathogenic subtype are proven to play a pathogenic role in IBS, it may be through their metabolic activity, which provides a target for new therapies and provides an intermediate marker for evaluating them.
Things
.
"The low FODMAP diet plan was first proposed by Monash University
.
In a related editorial, Professor Peter Gibson and Dr.
Emma Halmos of Monash University in Melbourne described the introduction and adoption of the FODMAP diet as a major change in the management of patients with irritable bowel syndrome (IBS) towards integrated care
.
They added that although “this is an effective symptomatic treatment, it brings risks associated with worsening eating disorders, challenging nutritional adequacy, and possibly inducing intestinal flora imbalance
.
” They pointed out some limitations of the study.
, Including improper assessment of FODMAP intake and fiber intake (which also affects the microbiome), but it has not been reported
.
They concluded: Nonetheless, the beauty of this research is not its definite nature, but its ability to create viable innovative hypotheses that can be tested through concentrated research
.
Maybe the FODMAP diet is more than just a symptom treatment
.
Reference materials: https://medicalxpress.
com/news/2021-11-distinct-gut-bacterial-profile-highly.
html Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital
.
Recommendation·Activity [Live] Twist Exome 2.
0, defining a new standard for exome sequencing.
Popular·Article Gut Microbiology [Nature] "What you eat is what you eat"-the evidence is found! Biomarkers that reveal how diet ultimately affects immunity through the gut microbiota [Cell Sub-Journal] Non-coding regions of the cancer genome-the discovery of new prognostic biomarkers Single cell sequencing [Cell] Using single cell sequencing technology to analyze recent 600,000 human cells, Ren Bing’s team draws an ultra-large-scale human genome single-cell chromatin accessibility map! Intestinal microbes [BMC sub-Journal] Open a new door to the treatment of gastrointestinal diseases-the discovery of microbiota Tumor research [Science sub Journal] Dr.
Feng Yang from Baylor College of Medicine and his team discovered that MAPK6 gene can promote cancer growth, and targeting MAPK6 provides an effective treatment strategy for cancer! Diseases and health [Cell News] Long-term large amounts of salt are harmful to health! Vigilance: Research reveals for the first time that a high-salt diet will cause trouble to the brain even if it does not increase blood pressure.
Tumor Research [Nature] Edible oil promotes cancer metastasis, and researchers are actively advancing clinical trials of the first new drug!
