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BMJ: The history of spontaneous abortion is associated with an increased risk of women's premature death, especially the risk of death from cardiovascular diseases

 Last Update: 2021-03-30
 Source: Internet
 Author: User

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Reducing the number of premature deaths caused by non-communicable diseases by one third by 2030 is a sustainable development goal of the United Nations.

However, more and more evidence shows that female-specific reproductive factors are related to a greater risk of death from non-communicable diseases.

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Spontaneous abortion is one of the most common adverse consequences of pregnancy, with an incidence of 12-24%.

However, the evidence linking spontaneous abortion and mortality is scarce and inconsistent.

This study is a prospective cohort study involving 116,429 female nurses of childbearing age (25-42 years old) living in one of 14 states in the United States.

116,429 female nurses of childbearing age (25-42 years old) living in one of 14 states in the United States.

Through a biennial questionnaire survey, the incidence of spontaneous abortion in pregnancy under 6 months was determined.

During the 24 years of follow-up, 2936 premature deaths were recorded, of which 1346 died of cancer and 269 died of cardiovascular disease.

After adjusting for confounding factors and updated diet and lifestyle factors, the incidence of spontaneous abortion is correlated with a hazard ratio of 1.

Adjusted for all causes and specific premature deaths based on the overall incidence of spontaneous abortions in 101681 women

Adjusted for all causes and specific premature deaths based on the overall incidence of spontaneous abortions in 101681 women Adjusted for all causes and specified premature deaths based on the overall incidence of spontaneous abortions in 101681 women Adjusted for the overall incidence of spontaneous abortions in 101681 women All causes and specific premature deaths

Spontaneous abortion is associated with an increased risk of premature death, especially an increased risk of death from cardiovascular diseases.

In addition, it is speculated that spontaneous abortion may trigger a cascade of reactions, leading to premature death, which may also interact with risk factors for cardiovascular disease.

：Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study BMJ 2021; 372 doi: https://doi.
org/10.
1136/bmj.
n530 (Published 24 March 2021)Cite this as: BMJ 2021;372:n530：Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study BMJ 2021; 372 doi: https://doi.
org/10.
1136/bmj.
n530 (Published 24 March 2021)Cite this as: BMJ 2021;372:n530：Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study BMJ 2021; 372 doi: https://doi.
org/10.
1136/bmj.
n530 (Published 24 March 2021)Cite this as: BMJ 2021;372:n530doi: https://doi.
org/10.
1136/bmj.
n530

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