Bone Marrow Transplant: Comparison of Fludarabine-Melphalan and Fludarabine-Triendosulfan as Conditioning Before Allogeneic Hematopoietic Cell Transplantation

Conditioning protocols for allogeneic hematopoietic cell transplantation (allo-HCT) protocols have changed considerably in recent years to achieve higher efficacy, lower toxicity, and better outcom.

Conditioning protocols for allogeneic hematopoietic cell transplantation (allo-HCT) protocols have changed considerably in recent years to achieve higher efficacy, lower toxicity, and better outcom.

This retrospective analysis from the Acute Leukemia Working Group (ALWP) registry of the European Bone Marrow Transplantation Society (EBMT) database included 1427 adult patients treated with Flu/Mel (n = 1005) or Flu/Treo (n = 422) (median age 52 year.

Figure 1: Effect of FluMel and FluTreo Conditioning on Results

Figure 1: Effect of FluMel and FluTreo Conditioning on Results

Table 1: Multivariate analysis of outcome variabl.

Table 1: Multivariate analysis of outcome variabl.

FluMel fludarabine/melphalan, FluTreo fludarabine/treosulfan, GvHD graft-versus-host disease, NRM non-relapse mortality, LFS leukemia-free survival, OS overall survival, GRFS GvHD-free relapse-free survival, secAML secondary to acute myeloid leukemia , CR complete remission, MSD-matched sibling donor, MUD-matched non-relative donor, Karnowski's performance profile, P.

FluMel fludarabine/melphalan, FluTreo fludarabine/treosulfan, GvHD graft-versus-host disease, NRM non-relapse mortality, LFS leukemia-free survival, OS overall survival, GRFS GvHD-free relapse-free survival, secAML secondary to acute myeloid leukemia , CR complete remission, MSD-matched sibling donor, MUD-matched non-relative donor, Karnowski's performance profile, P.

For patients conditioned with FluMel and FluTreo, 3-year overall survival (OS) was similar in both groups (54% .

The data from this study could serve as the basis for further research into additional drug/enhancing effects prior to allogeneic hematopoietic stem cell transplantati.

Original source:

Original source:

Duque-Afonso,.

Duque-Afonso,.
, Finke,.
, Labopin,.
et .
Comparison of fludarabine–melphalan and fludarabine–treosulfan as conditioning prior to allogeneic hematopoietic cell transplantation—a registry study on behalf of the EBMT Acute Leukemia Working Par.
Bone Marrow Transplant(202
https://d.

org/11038/s41409-022-01646-1 Duque-Afonso,.

, Finke,.

, Labopin,.

et .

Comparison of fludarabine–melphalan and fludarabine –treosulfan as conditioning prior to allogeneic hematopoietic cell transplantation—a registry study on behalf of the EBMT Acute Leukemia Working Par.

Bone Marrow Transplant(202
https://d.

org/11038/s41409-022-01646-1 et a.

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