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Br J Cancer: A new risk stratification prediction model for diffuse large B-cell lymphoma DLBCL

 Last Update: 2021-05-31
 Source: Internet
 Author: User

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Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma (NHL), accounting for approximately 32% and 38% of NHL cases in Western countries and China, respectively.

The R-CHOP regimen (rituximab combined with cyclophosphamide, doxorubicin, vincristine and prednisone) is the standard treatment for patients with all stages of DLBCL.

The International Prognostic Index (IPI) is composed of five independent prognostic factors, namely age, Eastern Cooperative Oncology Group performance status (ECOG PS), Ann Arbor staging, lactate dehydrogenase (LDH) and the number of external lymph nodes.

NPI model construction and calibration curve

Researchers analyzed the data of 1406 primary DLBCL patients at the Sun Yat-sen University Cancer Center and established an NPI model based on pre-treatment indicators to predict the patient's OS.

NPI model predicts overall survival rate of DLBCL patients

The calibration curve shows a satisfactory agreement between the patient's 5-year predicted OS and actual OS.

org/10.

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