Br J Cancer: Obesity, metabolic health and breast cancer risk are related

As the world's leading obesity is a major public health issue, but also major risk factors for chronic diseases, including heart vascular disease (CVD) and certain types of cancer
.

Previous epidemiological studies have shown that obesity increases the risk of breast cancer in postmenopausal women, but it is negatively correlated with the risk of premenopausal women

As the world's leading obesity is a major public health issue, but also major risk factors for chronic diseases, including heart vascular disease (CVD) and certain types of cancer

Recent studies have shown that there is a heterogeneous association between obesity and breast cancer risk among Asian women
.

Similar to general obesity, Metabolic Syndrome (MetS) is associated with an increased risk of breast cancer in postmenopausal women, but not in premenopausal women

Recent studies have shown that there is a heterogeneous association between obesity and breast cancer risk among Asian women

The study included 3,095,336 postmenopausal cancer-free women aged 40-79 who had undergone health check-ups from the National Health Care Service Center between 2009 and 2010
.

The incidence of invasive breast cancer in these women was recorded and followed up until 2018

The results show that obesity and MetS are related to the risk of breast cancer , but when the effects of obesity and MetS are adjusted for each other, the correlation weakens, especially the correlation of MetS
.

After adjusting the BMI, the researchers found that only elevated fasting blood glucose levels and waist circumference were associated with an increased risk of breast cancer

Research flow chart

Research flow chart

All in all, the results of the study revealed that obesity and MetS are independently associated with the increased risk of breast cancer in postmenopausal women
.

Therefore, postmenopausal women are encouraged to control their weight and their metabolic health

Obesity and MetS are independently related to the increased risk of breast cancer in postmenopausal women
.
Obesity and MetS are independently related to the increased risk of breast cancer in postmenopausal women
.

Original source:

Park, B.
, Kim, S.
, Kim, H.
et al.
Associations between obesity, metabolic health, and the risk of breast cancer in East Asian women .
Br J Cancer (22 September 2021).

Associations between obesity, metabolic health, and the risk of breast cancer in East Asian women

 

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