Brain aging or this gene is making a fuss.

Brain aging is a complex process that relies on precise regulation of multiple brain regions, compared with previous studies that have focused on a small number of brain regions and lack a transcription map covering multiple brain regions to analyze the molecular mechanisms behind brain aging, said Li Mingli, a member of the primate Evolutionary Genetics and Developmental Discipline Group at Kunming Animal Research Instituteresearchers based on these large-scale transcription group data analysis found that as we age, there is a significant decrease in the expression connection between the cerebral regions of the cortex and between the left and right hemispheres of the cortexIn each brain region, gene expression and selective splicing regulate brain aging through different mechanisms, while the molecular mechanisms of aging between different brain regions are much the sameanalysis of the gene co-expression network of transcription group data in older macaques, the researchers found nine modules that showed increased connectivity in older monkeys, and parsed a network-critical driving gene, PGLS, which may play an important role in brain agingBy overexpressing PGLS in mice, phenotypes, such as cognitive decline, decreased motor ability, and anorexia, were found to cause aging in miceFurther biological experiments have also shown that PGLS overexpression leads to synaptic loss and apoptosisAs a result, the researchers deduced that it was likely to be a new marker gene for brain agingit is understood that this is based on the "model animal phenotype and genetic research of the country's major scientific and technological infrastructure (primates)" construction of a research workThis facility will carry out systematic research on primate phenotypes and genetic types, and quickly and accurately analyze the phenotypes and intrinsic genetic relationships in the changing life phenomena, which is of great significance to the study of life science and medical health.