Brit J Cancer: Relationship between adult leukemia and long-term air pollution exposure.

Few population-based adult epidemiological studies have assessed the relationship between air pollution and leukemia.
recently published a research article in British Journal of Cancer, an authoritative journal in the field of oncology.
researchers used data from the Danish National Cancer Registry and air pollution exposure modeled by denmark's DEHM-UBM-AirGIS system to assess whether 1, 5 or 10-year average particulate matter (PM2.5), black carbon (BC), nitrogen dioxide (NO2) and ozone (O3) levels were associated with adult leukemia or its subsype.
the study included 14,986 adult cases diagnosed between 1989 and 2014 and 51,624 age, gender and time matching controls.
researchers used a conditional regression model that adjusted socio-demographic factors to assess the relationship between exposure to each pollutant and leukemia.
fully adjusted models showed higher average exposure to PM2.5 in 1, 5 and 10 years prior to diagnosis and a higher risk of leukemia in subjects (e.g., OR: 1.17 per 10 sg/m3 increase on the 10-year average, 95% CI: 1.03-1.32).
results were mainly driven by participants aged 70 and over (OR: 1.35, 95% CI: 1.15-1.58 per 10-year average increase of 10?g/m3).
for young participants, no correlation was found.
average PM2.5 exposure in the year before BC diagnosis was associated with a higher risk of acute myeloid and chronic lymphocytic leukemia.
, it can be seen that in the elderly, the higher risk of leukemia is associated with higher average PM2.5 concentrations in the year, 5 years and 10 years before diagnosis.
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