Cancers: Neutrophil extracellular traps are increased in chronic myeloid leukemia and are differentially affected by tyrosine kinase inhibitors

With the use of certain tyrosine kinase inhibitors (TKIs) for the treatment of chronic myeloid leukemia (CML), these drugs are also associated with some short- and long-term toxicities, and cardiovascular complications are increasingly being reported
.

Figure 1: Increased neutrophil NETs in CML patients

Figure 2: Ponatinib enhances NET formation in neutrophils from CML patients

Figure 3: BCR-ABL1-transduced ER-HoxB8 cell line system recapitulates CML, TKI effects and reveals PAD4-dependent NET phenotype

Pretreatment of neutrophils with TKIs is associated with differential effects on NET formation, BCR-ABL1 retrovirally transduced HoxB8 immortalized mouse hematopoietic progenitor cells differentiated into neutrophils in vitro showing H3cit and myeloperoxidation Biomass enzyme (MPO) expression was increased, which was consistent with excess NET formation

In conclusion, this article HoxB8 BCR-ABL1 -HoxB8

 

Original source:

Telerman, A.

Telerman, A.
; Granot, G.
; Leibovitch, C.
; Yarchovsky-Dolberg, O.
; Shacham-Abulafia, A.
; Partouche, S.
; Yeshurun, M.
; Ellis, MH; Raanani, P.
; Wolach, O.
Neutrophil Extracellular Traps Are Increased in Chronic Myeloid Leukemia and Are Differentially Affected by Tyrosine Kinase Inhibitors.
Cancers 2022 ,14 , 119.
https://doi.
org/10.
3390/cancers14010119 Leave a comment here